儿童和青少年抽动秽语综合征/慢性运动或发声抽动障碍患者抗弓形体抗体的血清阳性率：一项病例对照研究。

Seroprevalance Anti-Toxoplasma gondii antibodies in children and adolescents with tourette syndrome/chronic motor or vocal tic disorder: A case-control study.

机构信息

Department of Child and Adolescent Psychiatry, Gaziantep Dr. Ersin Arslan Training and Research Hospital, Gaziantep, Turkey.

Department of Child and Adolescent Psychiatry, University of Health Sciences, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul 34147, Turkey.

出版信息

Psychiatry Res. 2018 May;263:154-157. doi: 10.1016/j.psychres.2018.03.020. Epub 2018 Mar 8.

DOI:10.1016/j.psychres.2018.03.020

PMID:29554545

Abstract

Toxoplasma gondii infection may be associated with psychiatric disorders due to its neurological effects. The purpose of this study was to investigate the relation between tic disorders in children and adolescents and Anti-Toxoplasma IgG. 43 children diagnosed with Tourette's syndrome(TS) and 87 with chronic motor or vocal tic disorder(CMVTD), and 130 healthy volunteers, all aged 7-18, were enrolled. Anti-Toxoplasma IgG antibody levels obtained from blood specimens were investigated. Toxoplasma IgG positivity was determined in 16(37.2%) of the patients with TS, in 27(31%) of those with CMVTD and in 12(9.2%) members of the control group. Anti-Toxoplasma gondii antibody positivity was 5.827-fold higher in subjects with TS and 4.425-fold higher in subjects with CMVTD compared to the control group. Correlation was determined between a diagnosis of TS or CMVTD and Anti-Toxoplasma gondii antibodies. We think that it will be useful for the neuropsychiatric process associated with Anti-Toxoplasma gondii antibodies to be clarified.

摘要

弓形体感染可能与精神障碍有关，因为它具有神经影响。本研究的目的是调查儿童和青少年抽动障碍与抗弓形体 IgG 之间的关系。共纳入 43 例抽动秽语综合征（TS）患儿、87 例慢性运动或发声抽动障碍（CMVTD）患儿和 130 名健康志愿者，年龄均为 7-18 岁。检测了来自血液标本的抗弓形体 IgG 抗体水平。在 TS 患者中，16 例（37.2%）、CMVTD 患者中 27 例（31%）和对照组中 12 例（9.2%）患者抗弓形体 IgG 阳性。与对照组相比，TS 患者和 CMVTD 患者的抗弓形体抗体阳性率分别高出 5.827 倍和 4.425 倍。确定了 TS 或 CMVTD 的诊断与抗弓形体抗体之间的相关性。我们认为，阐明与抗弓形体抗体相关的神经精神过程将是有益的。