Karakaş Sacide, Ozlem Serçin, Tellioğlu Ayfer Metin, Ertabaklar Hatice, Ertuğ Sema
Adnan Menderes Üniversitesi Tıp Fakültesi, Anatomi Anabilim Dalı, Aydın, Türkiye.
Turkiye Parazitol Derg. 2012;36(3):133-6. doi: 10.5152/tpd.2012.32.
Blood transfusion therapy for Thalassaemia patients may cause transmission of some infectious agents to the recipients. As Toxoplasma gondii is a transfusion-transmitted parasite, we aimed to investigate anti-Toxoplasma antibodies.
We arranged two groups: patients and controls. There were 36 Thalassaemia cases in the patient group. The control group also included 36 healthy people (of the same ages and gender) who were selected by the one-to-one mapping method. Mean age was 18.1 ± 8.3 (4-35). Toxoplasma gondii IgG and IgM antibodies were analyzed by the Enzyme-Linked Immunosorbant Assay (ELISA).
We determined parasite-specific Toxoplasma gondii IgG antibodies in 7 (19.4%) and borderline levels of IgM antibody in 2 Thalassaemia major cases (5.5%). In the control group, parasite-specific IgG antibody was found in 5 cases (14%). Serum samples of patients with borderline levels were analyzed with an avidity test and were found to have high avidity. There were no significant differences between patient and control groups when considering the presence of anti-Toxoplasma IgG antibodies (p=0.752).
Although there is no significant statistical difference, we suggest that blood transfusion donors should be investigated for infectious agents such as Toxoplasma gondii.
地中海贫血患者的输血治疗可能会将一些传染原传播给受血者。由于弓形虫是一种可通过输血传播的寄生虫，我们旨在研究抗弓形虫抗体。
我们安排了两组：患者组和对照组。患者组有36例地中海贫血病例。对照组也包括36名健康人（年龄和性别相同），通过一对一匹配法选取。平均年龄为18.1±8.3（4 - 35岁）。采用酶联免疫吸附测定法（ELISA）分析弓形虫IgG和IgM抗体。
我们在7例（19.4%）地中海贫血重型病例中检测到寄生虫特异性弓形虫IgG抗体，在2例（5.5%）中检测到IgM抗体临界水平。在对照组中，5例（14%）检测到寄生虫特异性IgG抗体。对临界水平患者的血清样本进行亲和力检测，发现其具有高亲和力。在考虑抗弓形虫IgG抗体的存在时，患者组和对照组之间无显著差异（p = 0.752）。
虽然没有显著的统计学差异，但我们建议应对输血供血者进行诸如弓形虫等传染原的检测。
