Zhao Lijun, Xu Yang, Duo Xiaoling, Tian Xiaoying, Wang Peng
Department of Gynecology and Obstetrics, The Fifth People's Hospital of Jinan, Jinan, Shandong 250022, P.R. China.
Medical School of Jinan University, Guangzhou, Guangdong 510632, P.R. China.
Exp Ther Med. 2018 Apr;15(4):3765-3768. doi: 10.3892/etm.2018.5874. Epub 2018 Feb 15.
The effect of Shoutai pill on endometrial receptivity was analyzed. A total of 160 patients with spontaneous abortion were enrolled in this study. They were treated in the Fifth People's Hospital of Jinan (Shandong, China) from February 2014 to June 2016. The following treatment regimen was performed for the patients: after menstruation, Shoutai pill was taken as continuous medication for more than 5 menstrual cycles, the pill was taken 20 days per month, medication was stopped during menstruation, and contraceptive measures were taken during this period. Statistics were recorded of endometrial thickness and morphology, hemodynamic parameters of uterine spiral artery, including pulsatility index (PI) and resistance index (RI), endometrial LIF levels before and after treatment, and follicular development and ovulation were strictly monitored, and statistics of pregnancy were recorded. The endometrial thickness, type A endometrium and endometrial spiral arterial PI and RI levels, endometrial LIF levels were significantly improved after treatment (P<0.05); at the same time, pregnancy rate was 85%; during this treatment, patients had no significant side effects. In conclusion, improvement of endometrial acceptability with Shoutai pills can receive good effect, significantly promote embryo implantation and enhance pregnancy rate.
分析寿胎丸对子宫内膜容受性的影响。本研究共纳入160例自然流产患者。她们于2014年2月至2016年6月在济南市第五人民医院（中国山东）接受治疗。对患者实施以下治疗方案：月经来潮后，服用寿胎丸连续超过5个月经周期，每月服药20天，经期停药，此间采取避孕措施。记录子宫内膜厚度及形态、子宫螺旋动脉血流动力学参数，包括搏动指数（PI）和阻力指数（RI），治疗前后子宫内膜白血病抑制因子（LIF）水平，严格监测卵泡发育及排卵情况，并记录妊娠情况。治疗后子宫内膜厚度、A型子宫内膜及子宫内膜螺旋动脉PI和RI水平、子宫内膜LIF水平均显著改善（P<0.05）；同时，妊娠率为85%；治疗期间患者无明显副作用。综上所述，寿胎丸改善子宫内膜容受性可获得良好效果，显著促进胚胎着床并提高妊娠率。
