Stoicescu Manuela, Bungău Simona Gabriela, Ţiţ Delia Mirela, Muţiu Gabriela, Purza Anamaria Lavinia, Iovan Vasile Ciprian, Pop Ovidiu Laurean
Department of Preclinical Disciplines, Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Romania;
Rom J Morphol Embryol. 2017;58(4):1429-1434.
The main objective of this study is to draw the attention that repeated induced abortions in the women's physiological history are very dangerous and could lead to developing uterine cancer. The legislation regarding this practice is variable in different countries. Relevant information in the field concerning the numerous risk factors that appear with abortions must be taught in schools before girls start their sexual life and can help avoiding the complications that may follow. Also, the abortion should be an extreme measure that must be used only in extreme cases that threaten the mother's life or imply the health of the future child. The study comprised 258 women diagnosed with endometrial carcinoma, without any risks factors for this type of cancer, which were questioned regarding the abortions in previous history. The results show that the age when the uterine carcinoma appears is even lower as the number of abortions is higher and the number of this type of cancer cases is directly proportional with the number of abortions suffered. In order to avoid this fact we have to pay more attention to the legislation and education of the patients. Also, we followed the expression of both estrogen and progesterone hormone receptors, in the case of uterine cancer that occurred in women who had abortions in history compared to the expression of hormone receptors in the case of patients who did not have abortions.
本研究的主要目的是引起人们的注意,即女性生理史中的反复人工流产非常危险,可能会导致子宫癌的发生。不同国家关于这种做法的立法各不相同。在女孩开始性生活之前,学校必须教授该领域中有关人工流产出现的众多风险因素的相关信息,这有助于避免可能随之而来的并发症。此外,人工流产应该是一种极端措施,仅应在威胁母亲生命或涉及未来孩子健康的极端情况下使用。该研究包括258名被诊断为子宫内膜癌的女性,她们没有此类癌症的任何风险因素,并被询问了既往史中的人工流产情况。结果表明,子宫癌出现的年龄随着人工流产次数的增加而更低,且此类癌症病例的数量与所经历的人工流产次数成正比。为了避免这种情况,我们必须更加关注立法和对患者的教育。此外,我们还追踪了有过人工流产史的女性患子宫癌时雌激素和孕激素受体的表达情况,并与未进行过人工流产的患者的激素受体表达情况进行了比较。