Tataru Ana-Liana, Furau Gheorghe, Afilon Jompan, Ionescu Cringu, Dimitriu Mihai, Bratu Ovidiu Gabriel, Tit Delia Mirela, Bungau Simona, Furau Cristian
Department of Obstetrics and Gynecology, Arad County Clinical Hospital, 310023 Arad, Romania.
Department of Life Sciences, "Vasile Goldis" Western University of Arad, 310045 Arad, Romania.
J Clin Med. 2019 Jan 15;8(1):96. doi: 10.3390/jcm8010096.
Romania has the highest incidence of cervical cancer morbidity and mortality in Europe. This study identifies the major clusters for genital cancers, observes the features of genital and cervical cancer, and determines the extent to which cancer is a contributor to total Disability-Adjusted Life Year (DALY). Spatial analysis used Besag and Newell's method for genital cancer distribution, prevalence considered Arad County patients records (2008⁻2017), and DALY was determined according to WHO methodology and GLOBOCAN 2013 data. Diagnosis was established by histopathological examination of diagnostic biopsies or tissues obtained by surgical procedures, followed by clinical staging. 1695 women were recorded with genital cancer. Of these, 14.9% of lesions were in situ ( = 252) and 74.20% of cases were recorded in stage III or IV ( = 1258) ( < 0.0001). Over 90% of cervical cancers were squamous cell carcinomas (n = 728), 33.76% of endometrial cancers were adenocarcinomas in situ (n = 131), 32.42% of ovarian cancers were serous adenocarcinomas (n = 131), and 70.58% of vulvar cancers were squamous cell carcinomas (n = 48) ( < 0.0001). DALY/1000 was 67.2 for genital cancers and 33 for cervical cancers. From the point of view of Romanian women, cervical cancer remains one of the major problems that need to be dealt with and access to optimal treatment proves to be extremely limited.
罗马尼亚是欧洲宫颈癌发病率和死亡率最高的国家。本研究确定了生殖器癌症的主要聚集区，观察了生殖器癌和宫颈癌的特征，并确定了癌症在总伤残调整生命年（DALY）中所占的比例。空间分析采用Besag和Newell方法分析生殖器癌分布情况，患病率参考阿拉德县患者记录（2008 - 2017年），DALY根据世界卫生组织方法和全球癌症数据库2013年数据确定。通过对诊断性活检或手术获取的组织进行组织病理学检查来确诊，随后进行临床分期。记录了1695例患有生殖器癌的女性。其中，14.9%的病变为原位癌（n = 252），74.20%的病例记录为III期或IV期（n = 1258）（P < 0.0001）。超过90%的宫颈癌为鳞状细胞癌（n = 728），33.76%的子宫内膜癌为原位腺癌（n = 131），32.42%的卵巢癌为浆液性腺癌（n = 131），70.58%的外阴癌为鳞状细胞癌（n = 48）（P < 0.0001）。生殖器癌的DALY/1000为67.2，宫颈癌为33。从罗马尼亚女性的角度来看，宫颈癌仍然是需要解决的主要问题之一，而获得最佳治疗的机会极其有限。
