Nussbaum Laura Alexandra, Hogea Lavinia Maria, Chiriac Daniela Veronica, Grigoraş Mirela Loredana, Folescu Roxana, Bredicean Ana Cristina, Roşca Elena Cecilia Ildikó, Muncan Brandon, Nussbaum Liliana Maria, Simu Mihaela Adriana, Levai Codrina Mihaela
Discipline of Obstetrics-Gynecology, Discipline of Neurology, Department of Neurosciences, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania;
Rom J Morphol Embryol. 2017;58(4):1435-1446.
Relatively little research has been conducted on quantitative electroencephalography (QEEG) activity in patients with psychosis÷schizophrenia, especially in populations at-risk for the illness. Further studies are needed, in order to offer a possible endophenotypic marker of the cerebral functioning, associated with psychosis÷schizophrenia, in correlation with the neuroimaging, the neurocognitive, biochemical, molecular genetic tests, clinical aspects and the EEG activity from the same subjects. The aim was to investigate the role the QEEG abnormalities play in the etiology of psychosis÷schizophrenia, whether it can provide an endophenotype for psychosis and to make some correlations with the results obtained through magnetic resonance (MR) spectroscopy, for proper early detection and intervention. The prospective research was performed in the University Clinic of Child and Adolescent Psychiatry, Timisoara, Romania, involving 55 children with schizophrenia or ultra high-risk (UHR) for psychosis (groups 1, 2, 3 and 4) and 55 children as healthy controls (group 5). Groups 1 and 2 (28 children) are diagnosed with schizophrenia, groups 3 and 4 are UHR for psychosis (27 children), and group 5 represents healthy controls. Groups 1 and 3 had convulsive seizures in their personal history. We noticed: through the QEEG, numerous patterns of theta and delta activity, the diminished amplitude of the alpha band waves and the diminished alpha activity; also, the onset of psychosis was earlier at those presenting convulsive seizures in their personal history (groups 1 and 3); also, specific neuroimagistic abnormalities and modifications. The cerebral lesions, appearing during the development, raise the liability for schizophrenia. The high-risk for schizophrenia is correlated with the personal history of epilepsy, as well as with the family risk for psychosis.
关于精神病÷精神分裂症患者的定量脑电图（QEEG）活动的研究相对较少，尤其是在该疾病的高危人群中。需要进一步开展研究，以便提供一种可能与精神病÷精神分裂症相关的脑功能内表型标记物，并将其与神经影像学、神经认知、生化、分子遗传学检测、临床方面以及同一受试者的脑电图活动进行关联。目的是研究QEEG异常在精神病÷精神分裂症病因学中所起的作用，它是否能为精神病提供一种内表型，并与通过磁共振（MR）波谱获得的结果进行一些关联，以实现早期的准确检测和干预。这项前瞻性研究在罗马尼亚蒂米什瓦拉的儿童和青少年精神病大学诊所进行，涉及55名患有精神分裂症或处于精神病超高风险（UHR）的儿童（第1、2、3和4组）以及55名作为健康对照的儿童（第5组）。第1组和第2组（28名儿童）被诊断为精神分裂症，第3组和第4组为精神病UHR（27名儿童），第5组为健康对照。第1组和第3组在个人病史中有惊厥发作。我们注意到：通过QEEG，发现了大量的θ波和δ波活动模式、α波段波幅降低以及α活动减弱；此外，在个人病史中有惊厥发作的患者（第1组和第3组）精神病发作更早；还发现了特定的神经影像学异常和改变。发育过程中出现的脑损伤增加了患精神分裂症的易感性。精神分裂症的高风险与癫痫个人病史以及精神病家族风险相关。
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