Choubane Houcine, Garrido-Castro Alberto F, Alvarado Cuauhtemoc, Martín-Somer Ana, Guerrero-Corella Andrea, Daaou Mortada, Díaz-Tendero Sergio, Carmen Maestro M, Fraile Alberto, Alemán José
Departamento de Química Orgánica (Módulo 1), Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid 28049, Spain.
Departamento de Química (Módulo 13), Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid 28049, Spain.
Chem Commun (Camb). 2018 Mar 29;54(27):3399-3402. doi: 10.1039/C8CC01479E.
The addition of nucleophilic imines, using 2-hydroxybenzophenone as a chemical auxiliary, is presented. An intramolecular six-membered ring via hydrogen bonding that enhances the reactivity and selectivity is the key of this strategy, which is supported by DFT calculations and experimental trials.
本文介绍了以2-羟基二苯甲酮为化学助剂添加亲核亚胺的方法。通过氢键形成的分子内六元环增强了反应活性和选择性，这是该策略的关键，密度泛函理论计算和实验验证提供了支持。
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