Research Institute of Human Ecology, Seoul National University, Seoul 08826, Korea.
Department of Surgery, Soonchunhyang University Bucheon Hospital, Bucheon 14584, Korea.
Nutrients. 2018 Mar 20;10(3):380. doi: 10.3390/nu10030380.
We identified demographic, lifestyle, and clinical factors associated with vitamin D status among breast cancer survivors. The vitamin D prediction model may be a useful surrogate of circulating 25-hydroxvitamin D (25(OH)D) concentrations when this measure was not available. We included a total of 216 Korean breast cancer survivors aged 21-79 years who had been diagnosed with stage I to III primary breast cancer and had breast cancer surgery at least 6 months before enrolment. We used linear and logistic regressions to identify determinants for the plasma 25(OH)D concentrations and vitamin D insufficiency (plasma 25(OH)D concentration < 50 nmol/L). We observed that 48.85% of breast cancer survivors had a plasma 25(OH)D concentration less than 50 nmol/L. We identified the following determinants for plasma 25(OH)D concentrations: time since diagnosis (β = -0.005 for 1 month increment), supplementary vitamin D intake (β = 0.06 for 10 μg/day increment), season of the blood draw (β = 0.35 for summer; β = 0.32 for fall; β = 0.26 for winter vs. spring), smoking status (β = 0.28 for former vs. never), use of any supplement (β = -0.35 for non-use vs. use), and the parity number (β = -0.30 for three or more vs. one) were associated with the plasma 25(OH)D concentrations. In addition to the aforementioned variables, body mass index (BMI) was associated with the prevalence of vitamin D insufficiency. We identified the determinants for the plasma 25(OH)D concentrations among Korean breast cancer survivors. Future studies are needed to investigate the role of vitamin D in the progression of breast cancer among Korean breast cancer survivors.
我们确定了与乳腺癌幸存者维生素 D 状况相关的人口统计学、生活方式和临床因素。当无法获得循环 25-羟维生素 D（25（OH）D）浓度时，维生素 D 预测模型可能是其有用的替代物。我们共纳入了 216 名年龄在 21-79 岁之间的韩国乳腺癌幸存者，这些患者被诊断为 I 期至 III 期原发性乳腺癌，并且在入组前至少 6 个月接受了乳腺癌手术。我们使用线性和逻辑回归来确定血浆 25（OH）D 浓度和维生素 D 不足（血浆 25（OH）D 浓度<50nmol/L）的决定因素。我们发现 48.85%的乳腺癌幸存者的血浆 25（OH）D 浓度低于 50nmol/L。我们确定了以下决定血浆 25（OH）D 浓度的因素：诊断后时间（每月增加 0.005）、补充维生素 D 摄入（每天增加 10μg 为 0.06）、采血季节（夏季为 0.35；秋季为 0.32；冬季为 0.26，春季为 0.26）、吸烟状况（以前吸烟为 0.28，从不吸烟为 0.28）、使用任何补充剂（不使用为 0.35，使用为 0.35）和产次（三个或更多为 0.30，一个为 0.30）与血浆 25（OH）D 浓度相关。除了上述变量外，体重指数（BMI）与维生素 D 不足的患病率相关。我们确定了韩国乳腺癌幸存者血浆 25（OH）D 浓度的决定因素。需要进一步的研究来探讨维生素 D 在韩国乳腺癌幸存者中乳腺癌进展中的作用。
