患“神经性”球虫病犊牛血清中的不稳定神经毒素。
Labile neurotoxin in serum of calves with "nervous" coccidiosis.
作者信息
Isler C M, Bellamy J E, Wobeser G A
出版信息
Can J Vet Res. 1987 Apr;51(2):253-60.
Mouse inoculation was used to test for the presence of a toxin in the serum, cerebrospinal fluid, and intestinal contents collected from cases of bovine enteric coccidiosis, with and without neurological signs, and from control calves. Intravenous inoculation of mice with 10 mL/kg of serum from calves showing nervous signs caused effects significantly different from those caused by the inoculation of serum from calves not showing nervous signs and from control calves. The effect was particularly evident in female mice. At this dosage severe neurological signs such as loss of righting reflex, seizures and death occurred only with serum from calves with "nervous coccidiosis". The results suggest that serum from the calves with neurological signs contains a neurotoxin. This toxin appears to be highly labile. It was not present in the cerebrospinal fluid at levels comparable to those in the serum. The significance of this labile neurotoxin with respect to the pathogenesis of the neurological signs associated with bovine enteric coccidiosis is unknown.
采用小鼠接种法，检测从患有或未患有神经症状的牛肠道球虫病病例以及对照犊牛采集的血清、脑脊液和肠道内容物中是否存在毒素。给小鼠静脉注射10 mL/kg表现出神经症状的犊牛血清，其产生的效果与注射未表现出神经症状的犊牛血清及对照犊牛血清所产生的效果显著不同。这种效果在雌性小鼠中尤为明显。在此剂量下，只有来自患有“神经型球虫病”犊牛的血清会引发严重的神经症状，如翻正反射丧失、惊厥和死亡。结果表明，有神经症状的犊牛血清中含有一种神经毒素。这种毒素似乎高度不稳定。脑脊液中该毒素的含量与血清中的含量不相当。这种不稳定的神经毒素在与牛肠道球虫病相关的神经症状发病机制中的意义尚不清楚。
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