Department of Dermatology, School of Medicine, Pusan National University, Busan, Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Department of Dermatology, School of Medicine, Pusan National University, Busan, Korea; Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Korea; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
J Am Acad Dermatol. 2019 May;80(5):1322-1331. doi: 10.1016/j.jaad.2018.03.011. Epub 2018 Mar 17.
Evidence suggests that psoriasis might be associated with metabolic syndrome and an increased risk for cardiovascular disease.
To determine whether ustekinumab reduces systemic and vascular inflammation associated with metabolic syndrome and cardiovascular disease, measured using F-fluorodeoxyglucose positron emission tomography-computed tomography (F-FDG PET/CT).
Patients with psoriasis and healthy controls underwent baseline F-FDG PET/CT imaging. Patients with moderate-to-severe psoriasis were treated with ustekinumab and underwent F-FDG PET/CT again after a Psoriasis Area and Severity Index of 75 was achieved.
After a Psoriasis Area and Severity Index of 75 was achieved with ustekinumab treatment, standardized uptake values were reduced in the liver, spleen, and 5 parts of the aorta (P < .05).
Our study does not provide outcome data concerning cardiovascular events or metabolic syndrome; it only shows surrogate markers in a limited (Korean) population.
Ustekinumab treatment was significantly associated with decreased systemic and vascular inflammation related to metabolic syndrome and cardiovascular disease among patients with psoriasis.
有证据表明，银屑病可能与代谢综合征和心血管疾病风险增加有关。
通过 F-氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描（F-FDG PET/CT）测定，确定乌司奴单抗是否能降低与代谢综合征和心血管疾病相关的全身和血管炎症。
银屑病患者和健康对照者接受基线 F-FDG PET/CT 成像。中重度银屑病患者接受乌司奴单抗治疗，当银屑病面积和严重程度指数（PASI）达到 75 时再次进行 F-FDG PET/CT。
乌司奴单抗治疗 PASI 达到 75 后，肝脏、脾脏和主动脉 5 个部位的标准化摄取值均降低（P<.05）。
我们的研究没有提供有关心血管事件或代谢综合征的结果数据；它仅在有限的（韩国）人群中显示替代标志物。
乌司奴单抗治疗与银屑病患者代谢综合征和心血管疾病相关的全身和血管炎症降低显著相关。
