Department of Dermatology and Venereology, Aarhus University Hospital, P.P. Orums gade 11, DK-8000 Aarhus, Denmark.
Acta Derm Venereol. 2018 Apr 16;98(4):390-395. doi: 10.2340/00015555-2873.
The spleen is thought to play a role in atherosclerosis-associated immunity and cardiovascular research has indicated the existence of a cardio-splenic axis. The aim of this study was to assess splenic 18F-fluorodeoxyglucose uptake as a measure of systemic inflammation in patients with untreated psoriasis compared with historical controls assessed by positron emission tomography-computed tomography. Patients with moderate-to-severe psoriasis (n = 12, age 61.4 ± 4.1 years, 83% men, mean Psoriasis Area Severity Index score of 14.5) and controls (n = 23, age 60.4 ± 4.5 years, 87% men) were included in the study. Splenic inflammation was measured using the background-corrected spleen-liver-ratio (SLR) based on mean standardized uptake values. Mean ± SD SLR was increased in patients with psoriasis compared with controls (0.94 ± 0.11 vs. 0.82 ± 0.08; p = 0.001). SLR was significantly associated with aortic inflammation. These results support the existence of systemic inflammation in patients with psoriasis, and provide the rationale for a mechanistic link between psoriasis-driven inflammation and cardiovascular comorbidity through a spleen-atherosclerotic axis.
脾脏被认为在动脉粥样硬化相关免疫中发挥作用，心血管研究表明存在心脏-脾脏轴。本研究旨在评估未经治疗的银屑病患者与通过正电子发射断层扫描-计算机断层扫描评估的历史对照相比，脾脏 18F-氟脱氧葡萄糖摄取作为全身炎症的指标。将 12 例中度至重度银屑病患者（年龄 61.4±4.1 岁，83%为男性，平均银屑病面积严重程度指数评分为 14.5）和 23 例对照（年龄 60.4±4.5 岁，87%为男性）纳入本研究。使用基于平均标准化摄取值的背景校正脾脏-肝脏比（SLR）来测量脾脏炎症。与对照组相比，银屑病患者的平均 SLR 升高（0.94±0.11 对 0.82±0.08；p=0.001）。SLR 与主动脉炎症显著相关。这些结果支持银屑病患者存在全身炎症，并为通过脾脏-动脉粥样硬化轴银屑病驱动的炎症与心血管合并症之间的机制联系提供了依据。
