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尸检发现巨大冠状动脉瘤。

Giant coronary artery aneurysm at autopsy.

作者信息

Blackman Alicia, Mohammed Wayne

机构信息

Department of Anatomical Pathology, Eric Williams Medical Sciences Complex, Champs Fleurs, Trinidad and Tobago.

Department of ParaClinical, University of the West Indies at Saint Augustine, Champs Fleurs, Trinidad and Tobago.

出版信息

BMJ Case Rep. 2018 Mar 20;2018:bcr-2017-222816. doi: 10.1136/bcr-2017-222816.

DOI:10.1136/bcr-2017-222816
PMID:29559482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5878404/
Abstract

This case presents a woman in her early 20s who died after the sudden onset of chest pain. Five years earlier, she was investigated for a cardiac murmur during pregnancy and an echocardiogram revealed a 6.0×3.0 cm blood-filled sac compressing the left atrium and anterolateral aspect of the left ventricle with communication to the aortic root. She later had a CT scan of the chest with contrast, which showed aneurysmal dilatation of the left main coronary artery. She was placed on aspirin but defaulted from clinic 11 months post partum. At autopsy, a left coronary aneurysmal sac measuring 10.0×9.0 cm. was identified with a rupture measuring 7.0 cm in length and the pericardial sac contained 900 mL of blood with clots. The cause of death was cardiac tamponade secondary to rupture of the coronary artery aneurysm.

摘要

该病例为一名20岁出头的女性,因突发胸痛后死亡。5年前,她在孕期因心脏杂音接受检查,超声心动图显示一个6.0×3.0厘米的充满血液的囊袋,压迫左心房和左心室前外侧,并与主动脉根部相通。后来她接受了胸部增强CT扫描,显示左冠状动脉瘤样扩张。她开始服用阿司匹林,但产后11个月未再到诊所复诊。尸检时,发现一个10.0×9.0厘米的左冠状动脉瘤样囊袋,有一处7.0厘米长的破裂口,心包腔内有900毫升血液及血凝块。死亡原因是冠状动脉瘤破裂继发心脏压塞。

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本文引用的文献

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Giant coronary artery aneurysms: review and update.巨大冠状动脉瘤:综述与更新
Tex Heart Inst J. 2014 Dec 1;41(6):603-8. doi: 10.14503/THIJ-13-3896. eCollection 2014 Dec.
2
Excising a giant: report of a 7-cm coronary artery aneurysm.切除一个巨大肿物:关于一例7厘米冠状动脉瘤的报告。
Tex Heart Inst J. 2013;40(2):173-5.
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Giant saccular aneurysm of the left main coronary artery.左主干冠状动脉巨大囊状动脉瘤。
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Coronary artery aneurysm: a review and hypothesis regarding etiology.冠状动脉瘤:关于病因的综述与假说
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Aneurysm syndromes caused by mutations in the TGF-beta receptor.由转化生长因子-β受体突变引起的动脉瘤综合征
N Engl J Med. 2006 Aug 24;355(8):788-98. doi: 10.1056/NEJMoa055695.
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Large, isolated, congenital aneurysm of the anterior descending coronary artery.孤立性冠状动脉前降支巨大先天性动脉瘤
Br Heart J. 1993 Sep;70(3):274-5. doi: 10.1136/hrt.70.3.274.
10
Congenital coronary artery aneurysms.先天性冠状动脉瘤
Br Heart J. 1974 Apr;36(4):329-35. doi: 10.1136/hrt.36.4.329.