Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China.
Biomed Res Int. 2018 Feb 7;2018:4609750. doi: 10.1155/2018/4609750. eCollection 2018.
Renal vasoconstriction, oxidative stress, endothelial dysfunction, and apoptosis are the major causes of contrast-induced nephropathy (CIN). The aim of this study was to evaluate the protective effects of enalapril maleate and folic acid tablets on CIN in diabetic rats.
Thirty-two Sprague-Dawley rats were divided into four groups: CIN (C), CIN + enalapril maleate (CE), CIN + folic acid (CF), and CIN + enalapril maleate and folic acid tablets (CEF). CE, CF, and CEF rats were treated orally with enalapril maleate, folic acid, or enalapril maleate and folic acid tablets, respectively, for 5 days. CIN was induced in all groups followed by analyzed biochemical parameters, oxidative stress markers, endothelial dysfunction parameters, renal histopathology, and TUNEL staining.
Serum creatinine, blood urea nitrogen, and malondialdehyde levels were lower in the CEF group than in the C group. Homocysteine, superoxide dismutase, glutathione peroxidase, and nitric oxide levels were higher in the CEF group than in the C group. Histopathology scores and percentage of apoptotic kidney cells in the CEF group were significantly decreased compared with those in the C group.
These results suggest that enalapril maleate and folic acid tablets have a protective effect against CIN in diabetic rats.
肾血管收缩、氧化应激、内皮功能障碍和细胞凋亡是导致对比剂肾病（CIN）的主要原因。本研究旨在评估马来酸依那普利和叶酸片对糖尿病大鼠 CIN 的保护作用。
将 32 只 Sprague-Dawley 大鼠分为四组：CIN（C）组、CIN+马来酸依那普利（CE）组、CIN+叶酸（CF）组和 CIN+马来酸依那普利和叶酸片（CEF）组。CE、CF 和 CEF 组大鼠分别口服马来酸依那普利、叶酸或马来酸依那普利和叶酸片 5 天。所有组均诱导 CIN，然后分析生化参数、氧化应激标志物、内皮功能障碍参数、肾组织病理学和 TUNEL 染色。
CEF 组血清肌酐、血尿素氮和丙二醛水平低于 C 组。CEF 组同型半胱氨酸、超氧化物歧化酶、谷胱甘肽过氧化物酶和一氧化氮水平高于 C 组。CEF 组的组织病理学评分和凋亡肾细胞百分比明显低于 C 组。
这些结果表明，马来酸依那普利和叶酸片对糖尿病大鼠的 CIN 具有保护作用。
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