多奈哌齐对阿尔茨海默病经颅磁刺激参数的影响。
Effect of donepezil on transcranial magnetic stimulation parameters in Alzheimer's disease.
作者信息
Hwang Yun Tae, Rocchi Lorenzo, Hammond Paul, Hardy Chris Jd, Warren Jason D, Ridha Basil H, Rothwell John, Rossor Martin N
机构信息
Institute of Neurology, University College London, London, United Kingdom.
Brain and Mind Centre, University of Sydney, Camperdown, New South Wales, Australia.
出版信息
Alzheimers Dement (N Y). 2018 Mar 2;4:103-107. doi: 10.1016/j.trci.2018.02.001. eCollection 2018.
INTRODUCTION
There is a need for a reliable, noninvasive biomarker for Alzheimer's disease (AD). We assessed whether short-latency afferent inhibition (SAI), a transcranial magnetic stimulation paradigm that assesses cholinergic circuits of the brain, could become such a biomarker.
METHODS
Nineteen patients with AD underwent four SAI testing sessions. The timing of their usual donepezil dose was altered to create different cholinergic states for each session. This was compared to the SAI results from 20 healthy subjects.
RESULTS
SAI was not able to distinguish the different cholinergic states assessed in our study. There appeared to be a diurnal variation in cholinergic function in the control group, which was not present in the AD cohort.
DISCUSSION
SAI does not appear to have a role in diagnosis and assessment of AD patients. The loss of diurnal variation, however, warrants further investigation as it may provide further biochemical insights about AD.
引言
需要一种可靠的、非侵入性的阿尔茨海默病（AD）生物标志物。我们评估了短潜伏期传入抑制（SAI），一种评估大脑胆碱能回路的经颅磁刺激范式，是否能成为这样一种生物标志物。
方法
19名AD患者接受了4次SAI测试。改变他们通常服用多奈哌齐剂量的时间，为每次测试创造不同的胆碱能状态。将此与20名健康受试者的SAI结果进行比较。
结果
SAI无法区分我们研究中评估的不同胆碱能状态。对照组胆碱能功能似乎存在昼夜变化，而AD队列中不存在这种变化。
讨论
SAI似乎在AD患者的诊断和评估中不起作用。然而，昼夜变化的丧失值得进一步研究，因为它可能为AD提供更多的生化见解。
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