人体模型中的放射治疗诱导切伦科夫发光成像。

Radiotherapy-induced Cherenkov luminescence imaging in a human body phantom.

机构信息

Thayer School of Engineering at Dartmouth, Hanover, New Hampshire, United States.

University of Pennsylvania, Departments of Biophysics and Biochemistry and of Chemistry, Philadelphi, United States.

出版信息

J Biomed Opt. 2018 Mar;23(3):1-4. doi: 10.1117/1.JBO.23.3.030504.

DOI:10.1117/1.JBO.23.3.030504

PMID:29560623

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7560997/

Abstract

Radiation therapy produces Cherenkov optical emission in tissue, and this light can be utilized to activate molecular probes. The feasibility of sensing luminescence from a tissue molecular oxygen sensor from within a human body phantom was examined using the geometry of the axillary lymph node region. Detection of regions down to 30-mm deep was feasible with submillimeter spatial resolution with the total quantity of the phosphorescent sensor PtG4 near 1 nanomole. Radiation sheet scanning in an epi-illumination geometry provided optimal coverage, and maximum intensity projection images provided illustration of the concept. This work provides the preliminary information needed to attempt this type of imaging in vivo.

摘要

放射治疗会在组织中产生切伦科夫光发射，这种光可以被用来激活分子探针。本研究利用腋窝淋巴结区域的几何形状，来检测人体内体模组织中分子氧传感器的发光情况，从而检验这种方法的可行性。利用亚毫米级空间分辨率，检测深度达 30 毫米的区域是可行的，而总量接近 1 纳摩尔的磷光传感器 PtG4 可提供足够的信号。在 epi 照明几何形状下进行放射片扫描可提供最佳的覆盖范围，最大强度投影图像则可说明这一概念。这项工作为尝试体内这种类型的成像提供了所需的初步信息。