a Shandong Provincial Key Laboratory of Fine Chemicals , Qilu University of Technology (Shandong Academy of Sciences) , Jinan , China.
J Biomater Sci Polym Ed. 2018 Aug;29(11):1233-1249. doi: 10.1080/09205063.2018.1456024. Epub 2018 Mar 30.
Succinic anhydride (SAD) modified microcrystalline cellulose (MCC) films was prepared and used for the controlled release of the drug domperidone (dom). The morphology and chemical structure of the modified materials were characterized by SEM, FTIR, XRD and TG/DSC techniques. The physical properties, such as water uptake and swelling, light barrier properties, mechanical testing, in vitro degradation behavior, have been investigated. Results showed that the modified cellulose membranes exhibited good anti-UV properties, higher water uptake values, improved mechanical capacity and anti-biodegradability. In addition, the modified MCC films (MS) as the drug carrier indicated the controlled release of domperidone and the release mechanism was proposed using Korsmeyer-Peppas equation at pH 7.4. The developed drug delivery system possessed the profound significance in improving pharmacodynamics and bioavailability of drugs.
琥珀酸酐（SAD）改性微晶纤维素（MCC）薄膜的制备及其在药物多潘立酮（dom）的控制释放中的应用。采用 SEM、FTIR、XRD 和 TG/DSC 技术对改性材料的形貌和化学结构进行了表征。研究了改性纤维素膜的物理性能，如吸水率和溶胀度、阻隔性能、力学性能、体外降解行为等。结果表明，改性纤维素膜具有良好的抗紫外性能、更高的吸水率、提高的机械能力和抗生物降解性。此外，作为药物载体的改性 MCC 膜（MS）显示出多潘立酮的控制释放，并且在 pH 7.4 时使用 Korsmeyer-Peppas 方程提出了释放机制。所开发的药物传递系统在提高药物的药效学和生物利用度方面具有重要意义。
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