Shandong Provincial Key Laboratory of Fine Chemicals, Qilu University of Technology, Jinan, 250353, PR China.
Shandong Provincial Key Laboratory of Fine Chemicals, Qilu University of Technology, Jinan, 250353, PR China.
Int J Biol Macromol. 2017 Dec;105(Pt 3):1644-1653. doi: 10.1016/j.ijbiomac.2017.01.019. Epub 2017 Jan 5.
The functionalized cellulose ester MCN was firstly synthesized and used to cross-link gelatin by amidation between -NH in gelatin and active ester groups in MCN to form a composite polymer network Gel-MCN, which was confirmed by Van Slyke method, FTIR, XRD and TGA-DTG spectra. The model drug omeprazole was loaded in Gel-MCN composites mainly by electrostatic interaction and hydrogen bonds, which were certified by FTIR, XRD and TGA-DSC. Thermal stability, anti-biodegradability, mechanical property and surface hydrophobicity of the composites with different cross-linking extents and drug loading were systematically investigated. SEM images demonstrated the honeycomb structural cells of cross-linked gelatin networks and this ensured drug entrapment. The drug release mechanism was dominated by a combined effect of diffusion and degradation, and the release rate decreased with cross-linking degree increased. The developed drug delivery system had profound significance in improving pesticide effect and bioavailability of drugs.
首先合成了功能化纤维素酯 MCN，并通过 MCN 中的活性酯基与明胶中的 -NH 之间的酰胺化反应将其用于交联明胶，形成复合聚合物网络 Gel-MCN，这通过范斯莱克法、FTIR、XRD 和 TGA-DTG 光谱得到证实。通过静电相互作用和氢键将模型药物奥美拉唑主要负载在 Gel-MCN 复合材料中，这通过 FTIR、XRD 和 TGA-DSC 得到证实。系统研究了不同交联度和载药量的复合材料的热稳定性、抗生物降解性、力学性能和表面疏水性。SEM 图像证明了交联明胶网络的蜂窝状结构细胞，这确保了药物的包封。药物释放机制主要是扩散和降解的综合作用，释放速率随交联度的增加而降低。开发的药物传递系统在提高农药效果和药物生物利用度方面具有重要意义。
