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A comparative study of efficacy and safety of flupirtine versus piroxicam in postoperative pain in patients undergoing lower limb surgery.氟吡汀与吡罗昔康用于下肢手术患者术后疼痛的疗效和安全性比较研究。
J Pain Res. 2017 Oct 16;10:2471-2477. doi: 10.2147/JPR.S144647. eCollection 2017.
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HLA-DRB1*16: 01-DQB1*05: 02 is a novel genetic risk factor for flupirtine-induced liver injury.HLA-DRB1*16:01 - DQB1*05:02是氟吡汀诱导肝损伤的一种新型遗传危险因素。
Pharmacogenet Genomics. 2016 May;26(5):218-24. doi: 10.1097/FPC.0000000000000209.
3
Metabolic activation and analgesic effect of flupirtine in healthy subjects, influence of the polymorphic NAT2, UGT1A1 and GSTP1.氟吡汀在健康受试者中的代谢活化及镇痛作用，多态性NAT2、UGT1A1和GSTP1的影响。
Br J Clin Pharmacol. 2015 Mar;79(3):501-13. doi: 10.1111/bcp.12522.
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Flupirtine-induced liver injury--seven cases from the Berlin Case-control Surveillance Study and review of the German spontaneous adverse drug reaction reporting database.氟吡汀致肝损伤——来自柏林病例对照监测研究的 7 例病例和德国自发药物不良反应报告数据库的回顾。
Eur J Clin Pharmacol. 2014 Apr;70(4):453-9. doi: 10.1007/s00228-013-1631-4. Epub 2013 Dec 24.
5
The use of flupirtine in treatment of tinnitus.氟吡汀在耳鸣治疗中的应用。
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Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study.氟吡汀对克雅氏病患者认知功能的疗效：一项双盲研究。
Neurology. 2004 Mar 9;62(5):714-8. doi: 10.1212/01.wnl.0000113764.35026.ef.

Randomized controlled trial about pain medication flupirtine ignores recent pharmacovigilance warnings.

作者信息

Puljak Livia

机构信息

Laboratory for Pain Research, University of Split School of Medicine, Split, Croatia.

Department for Development, Research and Health Technology Assessment, Agency for Quality and Accreditation in Health Care and Social Welfare, Zagreb, Croatia.

出版信息

J Pain Res. 2018 Jan 12;11:177-180. doi: 10.2147/JPR.S154447. eCollection 2018.

DOI:10.2147/JPR.S154447
PMID:29560967
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5769781/
Abstract
摘要