Salembier L, De Ridder D, Van de Heyning P H
University Department of Otolaryngology and Head and Neck Surgery, Antwerp University Hospital, Belgium.
Acta Otolaryngol Suppl. 2006 Dec(556):93-5. doi: 10.1080/03655230600895242.
Flupirtine, a functional NMDA antagonist, does not seem to be efficacious in the treatment of tinnitus.
The purpose of this study was to investigate whether flupirtine has any beneficial effect on tinnitus perception.
Twenty-four patients were selected (6 female and 18 male patients) with continuous subjective tinnitus. Eight patients suffered left-sided tinnitus, 4 right-sided tinnitus and 12 bilateral tinnitus. We assessed the burden of the tinnitus by loudness visual analogue scale (VAS) and tinnitus questionnaire (TQ) according to Hallam et al., and Hiller and Goebel. All patients were treated with a 2 x 100 mg daily dosage of oral flupirtine for 3 weeks in an open prospective design.
There was no statistical effect on VAS and TQ of the treatment with flupirtine. Only one patient (4.2%) experienced a positive effect on the tinnitus but discontinued the treatment because of amnesia and concentration disorders.
氟吡汀作为一种功能性N-甲基-D-天冬氨酸（NMDA）拮抗剂，似乎对耳鸣治疗无效。
本研究旨在调查氟吡汀对耳鸣感知是否有任何有益作用。
选取24例持续性主观性耳鸣患者（6例女性，18例男性）。8例患者为左侧耳鸣，4例为右侧耳鸣，12例为双侧耳鸣。我们根据哈勒姆等人以及希勒和戈贝尔的方法，通过响度视觉模拟量表（VAS）和耳鸣问卷（TQ）评估耳鸣负担。所有患者采用开放前瞻性设计，口服氟吡汀，每日剂量2×100mg，持续3周。
氟吡汀治疗对VAS和TQ无统计学效应。仅1例患者（4.2%）耳鸣有积极效果，但因失忆和注意力障碍而停药。
