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中耳手术中通过操作鼓索神经引起的患者味觉变化。

Taste Changes in Patients With Middle Ear Surgery by Intraoperative Manipulation of Chorda Tympani Nerve.

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

出版信息

Otol Neurotol. 2018 Jun;39(5):591-596. doi: 10.1097/MAO.0000000000001780.

Abstract

OBJECTIVES

The aim of study was to evaluate the subjective changes of taste and salivation after middle ear surgery according to chorda tympani nerve (CTN) injury.

STUDY DESIGN

Prospective cohort study.

SETTING

Tertiary referral center.

PATIENTS

We enrolled 180 patients older than 13 years old who received middle ear surgery.

INTERVENTIONS

The patients were classified into cut, manipulated, and intact groups according to intraoperative assessments of the CTN. The patients responded taste and salivation surveys preoperatively, and 1, 3, and 6 months postoperatively.

MAIN OUTCOME MEASURES

We analyzed results of questionnaires including disturbance rates, severity and character to evaluate taste and salivation functions.

RESULTS

Taste disturbance rate was significantly improved in all groups during follow-up (p < 0.05). The incidence of taste disturbance did not differ significantly between the three groups at each follow-up (p > 0.05). The taste disturbance score improved gradually in the cut and intact groups (p < 0.001), but not in the manipulated group (p = 0.067). Among the patients with taste disturbance, hypoguesia was most common symptom. Incidence of salivation disturbance did not differ between the three groups (p = 0.298). However, this symptom improved significantly only in the intact group (p < 0.001). The taste and salivation disturbance rate was not different between patients with and without chronic otitis media at 3 and 6 months, and both groups showed significant improvement.

CONCLUSIONS

Prevalence of taste and salivation disturbance was similar between three groups until 6 months. However, taste disturbance did not improve in the manipulated group and salivation disturbance improved only in the intact group.

摘要

目的

研究旨在评估中耳手术后根据鼓索神经(CTN)损伤引起的味觉和唾液变化的主观变化。

研究设计

前瞻性队列研究。

设置

三级转诊中心。

患者

我们招募了 180 名年龄在 13 岁以上接受中耳手术的患者。

干预

根据术中对 CTN 的评估,患者被分为切断、操作和完整组。患者在术前、术后 1、3 和 6 个月时回答味觉和唾液调查问卷。

主要观察指标

我们分析了包括干扰率、严重程度和特征的问卷结果,以评估味觉和唾液功能。

结果

所有组在随访期间味觉障碍发生率均显著改善(p<0.05)。在每个随访中,三组之间的味觉障碍发生率无显著差异(p>0.05)。在切断和完整组中,味觉障碍评分逐渐改善(p<0.001),但在操作组中则没有(p=0.067)。在味觉障碍患者中,味觉减退是最常见的症状。三组之间唾液障碍的发生率无差异(p=0.298)。然而,仅在完整组中,这种症状显著改善(p<0.001)。在 3 个月和 6 个月时,慢性中耳炎患者和非慢性中耳炎患者的味觉和唾液障碍发生率无差异,且两组均有显著改善。

结论

直到 6 个月,三组之间味觉和唾液障碍的发生率相似。然而,操作组的味觉障碍没有改善,而完整组的唾液障碍仅有所改善。

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