Miller P, Watt G J, Elson C J
Int J Immunopharmacol. 1987;9(3):341-8. doi: 10.1016/0192-0561(87)90059-2.
Injection of mice with rat erythrocytes induces both anti-rat and autoimmune anti-erythrocyte responses. The autoimmune response is under active suppression which can be demonstrated by transfer of spleen cells from immunised donors to naive recipients subsequently injected with erythrocytes. This system allows investigation of immunemodulatory agents on responses to self and non-self antigens in three ways the autoantibody and anti-rat erythrocyte responses in mice receiving the drugs and rat erythrocytes; the responses in mice receiving transferred cells from dosed immunised donors; and the responses in mice receiving transferred cells from non dosed immunised donors and themselves receiving erythrocytes plus drugs. The effect of a range of compounds with immunemodulatory activity was examined in the three test situations and both suppression and enhancement of the autoimmune response were observed. Comparison of effects on anti-rat and autoimmune antibody levels has confirmed previous results that these responses are subject to separate controlling mechanisms.
给小鼠注射大鼠红细胞会诱导产生抗大鼠和自身免疫性抗红细胞反应。自身免疫反应受到主动抑制，这可通过将免疫供体的脾细胞转移至随后注射了红细胞的未免疫受体来证明。该系统能以三种方式研究免疫调节剂对自身和非自身抗原反应的影响：接受药物和大鼠红细胞的小鼠中的自身抗体和抗大鼠红细胞反应；接受来自给药免疫供体的转移细胞的小鼠中的反应；以及接受来自未给药免疫供体的转移细胞且自身接受红细胞加药物的小鼠中的反应。在这三种测试情况下检查了一系列具有免疫调节活性的化合物的作用，观察到了自身免疫反应的抑制和增强。对抗大鼠抗体和自身免疫抗体水平影响的比较证实了先前的结果，即这些反应受不同的控制机制支配。
