Croy B A, Wood W, King G J
J Immunol. 1987 Aug 15;139(4):1088-95.
Cells capable of suppressing the immune response of PBL to the mitogen PHA are associated with the epitheliochorial placenta during normal first pregnancy in the pig. Because placentation in the pig is noninvasive, these suppressor cells are not associated with decidua. Cells with similar activity are also found between the implantation sites and in the uterus of pseudopregnant pigs, suggesting that fetal trophoblast is not essential for recruitment of intrauterine suppressor cells. Cell separation studies demonstrate that two independent populations of suppressor cells are present in the pig uterus on day 28 of gestation, as well as a population of PHA-responsive cells. The inability of unseparated porcine uterine cells to respond to PHA, plus the reconstitution of suppression in remixing experiments, demonstrate directly that a functional, putative T effector cell population is blocked within the uterus during normal mammalian pregnancy.
在猪的首次正常妊娠期间，能够抑制外周血淋巴细胞（PBL）对丝裂原PHA免疫反应的细胞与上皮绒毛膜胎盘相关。由于猪的胎盘形成是非侵入性的，这些抑制细胞与蜕膜无关。在假孕猪的着床部位之间和子宫中也发现了具有类似活性的细胞，这表明胎儿滋养层对于子宫内抑制细胞的募集并非必不可少。细胞分离研究表明，在妊娠第28天猪子宫中存在两个独立的抑制细胞群体，以及一个PHA反应性细胞群体。未分离的猪子宫细胞无法对PHA作出反应，再加上混合实验中抑制作用的重建，直接证明在正常哺乳动物妊娠期间子宫内一个功能性的、假定的T效应细胞群体被阻断。
