阳离子抗菌肽不会改变. 的重组频率。
Cationic antimicrobial peptides do not change recombination frequency in .
机构信息
Evolutionary Biology, Institut für Biologie, Freie Universität Berlin, Berlin, Germany
Evolutionary Biology, Institut für Biologie, Freie Universität Berlin, Berlin, Germany.
出版信息
Biol Lett. 2018 Mar;14(3). doi: 10.1098/rsbl.2018.0006.
Abstract
Cationic antimicrobial peptides are ubiquitous immune effectors of multicellular organisms. We previously reported, that in contrast to most of the classic antibiotics, cationic antimicrobial peptides (AMPs) do not increase mutation rates in Here, we provide new evidence showing that AMPs do not stimulate or enhance bacterial DNA recombination in the surviving fractions. Recombination accelerates evolution of antibiotic resistance. Our findings have implications for our understanding of host-microbe interactions, the evolution of innate immune defences, and shed new light on the dynamic of antimicrobial-resistance evolution.
摘要
阳离子抗菌肽是多细胞生物普遍存在的免疫效应因子。我们之前的研究表明，与大多数经典抗生素不同，阳离子抗菌肽（AMPs）不会增加 中突变率。在这里，我们提供了新的证据表明，在存活的细菌群体中，AMPs 不会刺激或增强细菌 DNA 重组。重组会加速抗生素耐药性的进化。我们的研究结果对我们理解宿主-微生物相互作用、先天免疫防御的进化以及对抗生素耐药性进化的动态有重要意义。
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本文引用的文献
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