Department of Pharmacy, College of Pharmacy, Sunchon National University.
Department of Food and Nutrition, Kyungsung University.
Tohoku J Exp Med. 2018 Mar;244(3):219-229. doi: 10.1620/tjem.244.219.
Curcuma longa is rich in curcumin and used to treat disease and in food as a spice, especially in curry dishes. The objective of the present study was to determine whether curry intake reduces blood levels of heavy metals and hypertension (HTN) using Korean National Health and Nutrition Examination Survey 2013 data (n = 1,350). Study subjects (n = 1,350) were divided into two groups: 1) a curry intake group (n = 603), members of which had consumed a curry dish more than once a month over the previous year, and 2) a non-curry intake group (n = 747). Analysis showed the curry intake group had significantly lower heavy metal blood concentrations (Pb, Hg, and Cd) and blood concentrations of heavy metals were significantly associated with prevalence of HTN (P < 0.001 for Pb, Hg, and Cd). Curry intake also reduced the risk of HTN prevalence (odd ratios for curry intake vs. non-curry intake; Pb, 1.503 vs. 1.862; Hg, 1.112 vs. 1.149; Cd, 1.676 vs. 1.988). Logistic regression analysis was used to confirm the association between blood heavy metal levels and HTN. After adjusting for age, sex, lifetime smoking, and body mass index, the odd ratio of HTN was significant in the non-curry intake group, but not in the curry intake group, implying other factors influenced relations in the curry intake group. In view of the importance of curry consumption with reduced concentrations of heavy metals in blood and the prevalence of HTN, we suggest further well-designed clinical trials be conducted.
姜黄富含姜黄素，用于治疗疾病和作为食物中的香料，尤其是在咖喱菜肴中。本研究的目的是使用韩国 2013 年国家健康和营养检查调查（n = 1350）的数据，确定咖喱摄入量是否会降低血液中的重金属和高血压（HTN）水平。研究对象（n = 1350）分为两组：1）咖喱摄入量组（n = 603），成员在过去一年中每月至少食用一次咖喱菜；2）非咖喱摄入量组（n = 747）。分析表明，咖喱摄入量组的重金属血液浓度（Pb、Hg 和 Cd）显著降低，且重金属血液浓度与 HTN 患病率显著相关（Pb、Hg 和 Cd 的 P 值均<0.001）。咖喱摄入量还降低了 HTN 患病率的风险（与非咖喱摄入量相比，咖喱摄入量的比值比；Pb，1.503 比 1.862；Hg，1.112 比 1.149；Cd，1.676 比 1.988）。逻辑回归分析用于确认血液重金属水平与 HTN 之间的关联。在校正年龄、性别、终生吸烟和体重指数后，非咖喱摄入量组的 HTN 比值比有统计学意义，但在咖喱摄入量组无统计学意义，这表明其他因素影响了咖喱摄入量组的关系。鉴于咖喱消费与降低血液中重金属浓度和 HTN 患病率之间的重要性，我们建议进一步进行精心设计的临床试验。
