• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

双膦酸盐相关颌骨坏死(MRONJ)患者的影像学检查

Imaging in Patients with Bisphosphonate-Associated Osteonecrosis of the Jaws (MRONJ).

作者信息

Berg Britt-Isabelle, Mueller Andreas A, Augello Marcello, Berg Scott, Jaquiéry Claude

机构信息

Department of Cranio-Maxillofacial Surgery, University Hospital Basel, 4056 Basel, Switzerland.

Division of Oral and Maxillofacial Radiology, Columbia University Medical Center, New York, NY 10032, USA.

出版信息

Dent J (Basel). 2016 Sep 2;4(3):29. doi: 10.3390/dj4030029.

DOI:10.3390/dj4030029
PMID:29563471
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5806936/
Abstract

BACKGROUND

Bisphosphonate-associated osteonecrosis of the jaws (MRONJ/BP-ONJ/BRONJ) is a commonly seen disease. During recent decades, major advances in diagnostics have occurred. Once the clinical picture shows typical MRONJ features, imaging is necessary to determine the size of the lesion. Exposed bone is not always painful, therefore a thorough clinical examination and radiological imaging are essential when MRONJ is suspected.

METHODS

In this paper we will present the latest clinical update on the imaging options in regard to MRONJ: X-ray/Panoramic Radiograph, Cone Beam Computed Tomography (CBCT) and Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Nuclear Imaging, Fluorescence-Guided Bone Resection.

CONCLUSION

Which image modality is chosen depends not only on the surgeon's/practitioner's preference but also on the available imaging modalities. A three-dimensional imaging modality is desirable, and in severe cases necessary, for extended resections and planning of reconstruction.

摘要

背景

双膦酸盐相关颌骨坏死(MRONJ/BP-ONJ/BRONJ)是一种常见疾病。近几十年来,诊断方面取得了重大进展。一旦临床表现显示出典型的MRONJ特征,就需要进行影像学检查以确定病变大小。暴露的骨组织不一定会疼痛,因此,当怀疑患有MRONJ时,进行全面的临床检查和放射影像学检查至关重要。

方法

在本文中,我们将介绍有关MRONJ的影像学检查选项的最新临床进展:X线/全景X线片、锥形束计算机断层扫描(CBCT)和计算机断层扫描(CT)、磁共振成像(MRI)、核成像、荧光引导骨切除术。

结论

选择哪种成像方式不仅取决于外科医生/从业者的偏好,还取决于可用的成像方式。对于扩大切除术和重建规划,三维成像方式是理想的,在严重情况下是必要的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d9/5806936/a8122e2efa5e/dentistry-04-00029-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d9/5806936/e5bff328a765/dentistry-04-00029-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d9/5806936/4f75fcde886c/dentistry-04-00029-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d9/5806936/9c2bbd584f5e/dentistry-04-00029-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d9/5806936/f1ac8c844e7d/dentistry-04-00029-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d9/5806936/df06ad9e048a/dentistry-04-00029-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d9/5806936/78a18ceb68b3/dentistry-04-00029-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d9/5806936/6163d066ec41/dentistry-04-00029-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d9/5806936/6d49fde51285/dentistry-04-00029-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d9/5806936/a8122e2efa5e/dentistry-04-00029-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d9/5806936/e5bff328a765/dentistry-04-00029-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d9/5806936/4f75fcde886c/dentistry-04-00029-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d9/5806936/9c2bbd584f5e/dentistry-04-00029-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d9/5806936/f1ac8c844e7d/dentistry-04-00029-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d9/5806936/df06ad9e048a/dentistry-04-00029-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d9/5806936/78a18ceb68b3/dentistry-04-00029-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d9/5806936/6163d066ec41/dentistry-04-00029-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d9/5806936/6d49fde51285/dentistry-04-00029-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d9/5806936/a8122e2efa5e/dentistry-04-00029-g009.jpg

相似文献

1
Imaging in Patients with Bisphosphonate-Associated Osteonecrosis of the Jaws (MRONJ).双膦酸盐相关颌骨坏死(MRONJ)患者的影像学检查
Dent J (Basel). 2016 Sep 2;4(3):29. doi: 10.3390/dj4030029.
2
Do various imaging modalities provide potential early detection and diagnosis of medication-related osteonecrosis of the jaw? A review.各种影像学方法能否提供药物相关性颌骨坏死的潜在早期检测和诊断?综述。
Dentomaxillofac Radiol. 2021 Sep 1;50(6):20200417. doi: 10.1259/dmfr.20200417. Epub 2021 Jan 15.
3
CT imaging features of antiresorptive agent-related osteonecrosis of the jaw/medication-related osteonecrosis of the jaw.抗吸收剂相关性颌骨坏死/药物相关性颌骨坏死的 CT 影像学特征。
Dentomaxillofac Radiol. 2018 May;47(4):20170323. doi: 10.1259/dmfr.20170323. Epub 2018 Feb 13.
4
The Role of Cone Beam Computed Tomography (CBCT) in the Diagnosis and Clinical Management of Medication-Related Osteonecrosis of the Jaw (MRONJ).锥形束计算机断层扫描(CBCT)在颌骨药物相关性骨坏死(MRONJ)诊断及临床管理中的作用
Diagnostics (Basel). 2024 Aug 6;14(16):1700. doi: 10.3390/diagnostics14161700.
5
A comparison of the cone beam computed tomography findings in medication-related osteonecrosis of the jaws related to denosumab versus bisphosphonates: an observational pilot study.比较 denosumab 与双膦酸盐相关的药物相关性颌骨骨坏死的锥形束 CT 表现:一项观察性初步研究。
Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Apr;129(4):411-417. doi: 10.1016/j.oooo.2019.09.010. Epub 2019 Sep 26.
6
Medication-Related Osteonecrosis of the Jaw-Comparison of Bone Imaging Using Ultrashort Echo-Time Magnetic Resonance Imaging and Cone-Beam Computed Tomography.药物相关性下颌骨坏死的骨影像学比较:超短回波时间磁共振成像与锥形束计算机断层摄影。
Invest Radiol. 2020 Mar;55(3):160-167. doi: 10.1097/RLI.0000000000000617.
7
Surgical evaluation of panoramic radiography and cone beam computed tomography for therapy planning of bisphosphonate-related osteonecrosis of the jaws.全景X线摄影和锥形束计算机断层扫描在双膦酸盐相关颌骨骨坏死治疗计划中的外科评估
Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Apr;121(4):419-24. doi: 10.1016/j.oooo.2015.11.012. Epub 2015 Nov 24.
8
Identifying MRONJ-affected bone with digital fusion of functional imaging (FI) and cone-beam computed tomography (CBCT): case reports and hypothesis.通过功能成像(FI)与锥形束计算机断层扫描(CBCT)的数字融合识别受药物性颌骨坏死(MRONJ)影响的骨骼:病例报告与假说
Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Mar;123(3):e106-e116. doi: 10.1016/j.oooo.2016.11.007. Epub 2016 Nov 28.
9
Three-dimensional radiologic-pathologic correlation of medication-related osteonecrosis of the jaw using 3D bone SPECT/CT imaging.三维骨 SPECT/CT 成像在药物相关性颌骨坏死中的放射-病理相关性研究。
Dentomaxillofac Radiol. 2019 Dec;48(8):20190208. doi: 10.1259/dmfr.20190208. Epub 2019 Jul 11.
10
Radiographic Evaluation of Medication-Related Osteonecrosis of the Jaw (MRONJ) With Different Primary Cancers and Medication Therapies.不同原发性癌症及药物治疗相关颌骨骨坏死(MRONJ)的影像学评估
Cureus. 2023 Aug 1;15(8):e42830. doi: 10.7759/cureus.42830. eCollection 2023 Aug.

引用本文的文献

1
Treatment of Medication-Related Osteonecrosis of the Jaw Without and With the Use of Advanced Platelet-Rich Fibrin: A Retrospective Clinical Study.不使用和使用高级富血小板纤维蛋白治疗药物相关性颌骨坏死:一项回顾性临床研究
J Funct Biomater. 2025 May 14;16(5):180. doi: 10.3390/jfb16050180.
2
Case Report: Virtual surgery and 3D printing in a medication-related osteonecrosis of the jaws (MRONJ) pathological mandibular fracture.病例报告:虚拟手术与3D打印在药物相关性颌骨坏死(MRONJ)病理性下颌骨骨折中的应用
Front Oral Health. 2025 Mar 28;6:1520195. doi: 10.3389/froh.2025.1520195. eCollection 2025.
3
Potential role of comprehensive dental care in preventing medication related osteonecrosis of the jaw (MRONJ): a single centre study.

本文引用的文献

1
Bone scintigraphy predicts bisphosphonate-induced osteonecrosis of the jaw (BRONJ) in patients with metastatic castration-resistant prostate cancer (mCRPC).骨闪烁显像术可预测转移性去势抵抗性前列腺癌(mCRPC)患者双膦酸盐相关性颌骨坏死(BRONJ)。
Clin Oral Investig. 2016 May;20(4):753-8. doi: 10.1007/s00784-015-1563-8. Epub 2015 Aug 26.
2
Mandibular inferior cortical bone thickness on panoramic radiographs in patients using bisphosphonates.使用双膦酸盐类药物患者全景X线片上的下颌骨皮质骨厚度
Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 May;119(5):584-92. doi: 10.1016/j.oooo.2015.02.005. Epub 2015 Feb 14.
3
综合口腔护理在预防药物相关性颌骨坏死(MRONJ)中的潜在作用:单中心研究。
BMC Oral Health. 2024 Oct 26;24(1):1291. doi: 10.1186/s12903-024-05081-0.
4
Clinical Performance of Implant-Supported Prostheses in the Rehabilitation of Patients Previously Treated for Medication-Related Osteonecrosis of the Jaws (MRONJ): A Systematic Review.种植体支持式修复体用于曾接受药物相关性颌骨坏死(MRONJ)治疗患者康复的临床性能:一项系统评价
Cureus. 2024 Jun 4;16(6):e61658. doi: 10.7759/cureus.61658. eCollection 2024 Jun.
5
A large animal model of periodontal defects in bisphosphonate-related osteonecrosis of the jaw: a comparison of clinical and radiological findings.双膦酸盐相关颌骨坏死中牙周缺损的大型动物模型:临床与影像学表现比较
J Periodontal Implant Sci. 2024 Jun;54(3):139-148. doi: 10.5051/jpis.2204860243. Epub 2023 Jul 7.
6
Correlation of dynamic contrast-enhanced bone perfusion with morphologic ultra-short echo time MR imaging in medication-related osteonecrosis of the jaw.药物相关性颌骨骨坏死的动态对比增强骨灌注与形态超短回波时间磁共振成像的相关性。
Dentomaxillofac Radiol. 2022 Feb 1;51(2):20210036. doi: 10.1259/dmfr.20210036. Epub 2021 Aug 18.
7
Do various imaging modalities provide potential early detection and diagnosis of medication-related osteonecrosis of the jaw? A review.各种影像学方法能否提供药物相关性颌骨坏死的潜在早期检测和诊断?综述。
Dentomaxillofac Radiol. 2021 Sep 1;50(6):20200417. doi: 10.1259/dmfr.20200417. Epub 2021 Jan 15.
8
Tomographic study of Jaw bone changes in patients with bisphosphonate-related osteonecrosis.双膦酸盐相关骨坏死患者颌骨变化的断层扫描研究
J Clin Exp Dent. 2020 Mar 1;12(3):e285-e290. doi: 10.4317/jced.56265. eCollection 2020 Mar.
9
Comparative evaluation of SPECT/CT and CBCT in patients with mandibular osteomyelitis and osteonecrosis.SPECT/CT 与 CBCT 在下颌骨骨髓炎和骨坏死患者中的对比评估。
Clin Oral Investig. 2019 Dec;23(12):4213-4222. doi: 10.1007/s00784-019-02862-8. Epub 2019 Feb 26.
American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update.
美国口腔颌面外科医师协会关于药物相关性颌骨坏死的立场文件——2014年更新版
J Oral Maxillofac Surg. 2014 Oct;72(10):1938-56. doi: 10.1016/j.joms.2014.04.031. Epub 2014 May 5.
4
Sinus mucosal thickening in bisphosphonate-related osteonecrosis of the jaws: a case-control study.双膦酸盐相关颌骨坏死中的鼻窦黏膜增厚:一项病例对照研究
ORL J Otorhinolaryngol Relat Spec. 2014;76(4):199-206. doi: 10.1159/000365930. Epub 2014 Aug 28.
5
Auto-fluorescence of the bone and its use for delineation of bone necrosis.骨骼的自体荧光及其在骨坏死轮廓描绘中的应用。
Int J Oral Maxillofac Surg. 2014 Nov;43(11):1391-3. doi: 10.1016/j.ijom.2014.07.017. Epub 2014 Aug 12.
6
Fluorodeoxyglucose positron emission tomography with computed tomography detects greater metabolic changes that are not represented by plain radiography for patients with osteonecrosis of the jaw.对于颌骨坏死患者,氟脱氧葡萄糖正电子发射断层扫描联合计算机断层扫描能检测到更大的代谢变化,而这些变化在X线平片中无法显示。
J Oral Maxillofac Surg. 2014 Oct;72(10):1957-65. doi: 10.1016/j.joms.2014.04.017. Epub 2014 Apr 24.
7
Cone beam computed tomography for diagnosis of bisphosphonate-related osteonecrosis of the jaw: evaluation of quantitative and qualitative image parameters.锥形束计算机断层扫描在诊断双膦酸盐相关颌骨骨坏死中的应用:定量和定性图像参数评估
Skeletal Radiol. 2014 Dec;43(12):1669-78. doi: 10.1007/s00256-014-1951-1. Epub 2014 Jul 5.
8
Staging of osteonecrosis of the jaw requires computed tomography for accurate definition of the extent of bony disease.颌骨骨坏死的分期需要进行计算机断层扫描,以准确界定骨病的范围。
Br J Oral Maxillofac Surg. 2014 Sep;52(7):603-8. doi: 10.1016/j.bjoms.2014.04.009. Epub 2014 May 22.
9
Effect of antiresorptive drugs on bony turnover in the jaw: denosumab compared with bisphosphonates.抗吸收药物对颌骨骨转换的影响:地诺单抗与双膦酸盐的比较。
Br J Oral Maxillofac Surg. 2014 Apr;52(4):308-13. doi: 10.1016/j.bjoms.2014.01.021. Epub 2014 Feb 26.
10
A simple evaluation method for early detection of bisphosphonate-related osteonecrosis of the mandible using computed tomography.一种使用计算机断层扫描早期检测双膦酸盐相关下颌骨坏死的简单评估方法。
J Craniomaxillofac Surg. 2014 Sep;42(6):924-9. doi: 10.1016/j.jcms.2014.01.012. Epub 2014 Jan 14.