Abraham G E, Rumley R E
J Reprod Med. 1987 Jun;32(6):405-22.
The clinical, biochemical and endocrine effects of a total dietary program were evaluated in patients with the premenstrual tension syndromes (PMTS). The program consisted of dietary guidelines and nutritional supplementation. Open trials suggested that an initial dosage of the supplement consisting of six tablets daily gave the best symptomatic relief during the first three to six months. Double-blind studies confirmed that a daily average of six tablets decreased PMTS symptom scores to significantly lower levels than did the placebo. A significantly higher percentage of PMTS patients reported feeling better on the dietary program than did those on the placebo. Although significant changes were observed in some liver function tests, the values were within the normal ranges. The dietary program, implemented for three to six months, decreased serum estradiol 17-beta and increased serum progesterone levels during the midluteal phase in PMTS patients. Nonresponders using the program should be reevaluated and treated according to the results of the reevaluation and the PMTS symptoms.
对患有经前紧张综合征（PMTS）的患者评估了整体饮食方案的临床、生化和内分泌效应。该方案包括饮食指南和营养补充。开放性试验表明，补充剂的初始剂量为每日6片，在前3至6个月内症状缓解效果最佳。双盲研究证实，每日平均服用6片使PMTS症状评分显著低于安慰剂组。与服用安慰剂的患者相比，有显著更高比例的PMTS患者报告称遵循饮食方案后感觉更好。尽管在一些肝功能测试中观察到了显著变化，但数值仍在正常范围内。对PMTS患者实施3至6个月的饮食方案后，在黄体中期血清雌二醇17-β水平降低，血清孕酮水平升高。对使用该方案无反应者应重新评估，并根据重新评估结果和PMTS症状进行治疗。
