Hahn B H, Ando D G, Dunn K, Ebling F M, Sercarz E
J Rheumatol Suppl. 1987 Jun;14 Suppl 13:143-8.
There is good evidence that the idiotypic network of the immune system can be implicated in the synthesis of pathogenic subsets of autoantibodies. The individual with systemic lupus erythematosus must have the immunoglobulin gene information which permits synthesis of those idiotypes, helper T populations which drive or select for the B cells producing them, and inadequate mechanisms to suppress those activated effector cells.
有充分证据表明，免疫系统的独特型网络可能与自身抗体致病性亚群的合成有关。系统性红斑狼疮患者必定具备能合成那些独特型的免疫球蛋白基因信息、驱动或选择产生这些独特型的B细胞的辅助性T细胞群体，以及抑制那些活化效应细胞的机制不足。
