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Updates on immunotherapy for colorectal cancer.结直肠癌免疫治疗的最新进展。
J Gastrointest Oncol. 2018 Feb;9(1):160-169. doi: 10.21037/jgo.2018.01.17.
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Is There a Role for Programmed Death Ligand-1 Testing and Immunotherapy in Colorectal Cancer With Microsatellite Instability? Part I-Colorectal Cancer: Microsatellite Instability, Testing, and Clinical Implications.程序性死亡配体-1检测及免疫疗法在微卫星不稳定的结直肠癌中是否有作用？第一部分——结直肠癌：微卫星不稳定、检测及临床意义
Arch Pathol Lab Med. 2018 Jan;142(1):17-25. doi: 10.5858/arpa.2017-0040-RA. Epub 2017 Nov 16.
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Immunotherapy in microsatellite instability metastatic colorectal cancer: Current status and future perspectives.微卫星不稳定转移性结直肠癌的免疫治疗：现状与未来展望。
J Clin Transl Res. 2021 Aug 4;7(4):511-522. eCollection 2021 Aug 26.
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The Potential Value of Immunotherapy in Colorectal Cancers: Review of the Evidence for Programmed Death-1 Inhibitor Therapy.免疫疗法在结直肠癌中的潜在价值：程序性死亡-1抑制剂治疗的证据综述
Clin Colorectal Cancer. 2016 Dec;15(4):285-291. doi: 10.1016/j.clcc.2016.07.007. Epub 2016 Jul 22.
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Is There a Role for Programmed Death Ligand-1 Testing and Immunotherapy in Colorectal Cancer With Microsatellite Instability? Part II-The Challenge of Programmed Death Ligand-1 Testing and Its Role in Microsatellite Instability-High Colorectal Cancer.程序性死亡配体-1检测及免疫疗法在微卫星不稳定型结直肠癌中是否有作用？第二部分——程序性死亡配体-1检测的挑战及其在微卫星高度不稳定型结直肠癌中的作用
Arch Pathol Lab Med. 2018 Jan;142(1):26-34. doi: 10.5858/arpa.2017-0041-RA. Epub 2017 Nov 9.
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Microsatellite instability in colorectal cancer: overview of its clinical significance and novel perspectives.结直肠癌中的微卫星不稳定性：临床意义概述及新观点
Clin Adv Hematol Oncol. 2018 Nov;16(11):735-745.
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Metastatic Pattern of Stage IV Colorectal Cancer with High-Frequency Microsatellite Instability as a Prognostic Factor.高频微卫星不稳定作为预后因素的IV期结直肠癌转移模式
Anticancer Res. 2017 Jan;37(1):239-247. doi: 10.21873/anticanres.11313.
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Nivolumab for the treatment of colorectal cancer.纳武利尤单抗治疗结直肠癌。
Expert Rev Anticancer Ther. 2018 Jul;18(7):611-618. doi: 10.1080/14737140.2018.1480942. Epub 2018 Jun 11.
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The evolving role of immune oncology in colorectal cancer.免疫肿瘤学在结直肠癌中不断演变的作用。
Chin Clin Oncol. 2018 Apr;7(2):17. doi: 10.21037/cco.2018.04.07.
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Combined Microsatellite Instability and Elevated Microsatellite Alterations at Selected Tetranucleotide Repeats (EMAST) Might Be a More Promising Immune Biomarker in Colorectal Cancer.联合微卫星不稳定性和在选定四核苷酸重复序列处升高的微卫星改变（EMAST）可能是结直肠癌更有前途的免疫生物标志物。
Oncologist. 2019 Dec;24(12):1534-1542. doi: 10.1634/theoncologist.2019-0171. Epub 2019 Jul 10.
引用本文的文献
1
Effective SMOTE boost with deep learning for IDC identification in whole-slide images.用于全切片图像中浸润性导管癌识别的基于深度学习的有效合成少数类过采样技术增强算法
PLoS One. 2025 Sep 3;20(9):e0329078. doi: 10.1371/journal.pone.0329078. eCollection 2025.
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The effect of FeO biosynthesized through the green synthesis of Silybum marianum and HA in the targeted delivery of 5-Fluorouracil to HCT116 cell line.通过水飞蓟素绿色合成法生物合成的FeO及透明质酸在将5-氟尿嘧啶靶向递送至HCT116细胞系中的作用。
Daru. 2025 Jul 31;33(2):27. doi: 10.1007/s40199-025-00568-9.
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Precision oncolytic viral therapy in colorectal cancer: Genetic targeting and immune modulation for personalized treatment (Review).结直肠癌的精准溶瘤病毒疗法：用于个性化治疗的基因靶向和免疫调节（综述）
Int J Mol Med. 2025 Jul;56(1). doi: 10.3892/ijmm.2025.5545. Epub 2025 May 9.
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Comprehensive identification of hub mRNAs and lncRNAs in colorectal cancer using galaxy: an in silico transcriptome analysis.使用Galaxy全面鉴定结直肠癌中的枢纽mRNA和lncRNA：一项计算机转录组分析
Discov Oncol. 2025 Mar 8;16(1):282. doi: 10.1007/s12672-025-02026-z.
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Nomogram for predicting the development of pneumonia after colorectal cancer surgery.预测结直肠癌手术后肺炎发生的列线图。
Sci Rep. 2025 Mar 3;15(1):7417. doi: 10.1038/s41598-025-92106-5.
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Potentials of N-Acyl Hydrazones Against Colorectal Cancer: A Mini Review.N-酰基腙类化合物抗结直肠癌的潜力：一篇综述
Anticancer Agents Med Chem. 2025;25(17):1273-1286. doi: 10.2174/0118715206356253241223040825.
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Directed protein engineering identifies a human TIM-4 blocking antibody that enhances anti-tumor response to checkpoint inhibition in murine colon carcinoma.定向蛋白质工程鉴定出一种人TIM-4阻断抗体，该抗体可增强小鼠结肠癌对检查点抑制的抗肿瘤反应。
Antib Ther. 2024 Sep 23;7(4):324-334. doi: 10.1093/abt/tbae026. eCollection 2024 Oct.
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Efficacy and safety of PD-1/PD-L1 and CTLA-4 immune checkpoint inhibitors in the treatment of advanced colorectal cancer: a systematic review and meta-analysis.PD-1/PD-L1 和 CTLA-4 免疫检查点抑制剂治疗晚期结直肠癌的疗效和安全性：系统评价和荟萃分析。
Front Immunol. 2024 Nov 1;15:1485303. doi: 10.3389/fimmu.2024.1485303. eCollection 2024.
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In-depth study of pyroptosis-related genes and immune infiltration in colon cancer.深入研究结肠癌中与细胞焦亡相关的基因和免疫浸润。
PeerJ. 2024 Oct 29;12:e18374. doi: 10.7717/peerj.18374. eCollection 2024.
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Myeloid‑derived suppressor cells: Key immunosuppressive regulators and therapeutic targets in colorectal cancer (Review).髓源性抑制细胞：结直肠癌中关键的免疫抑制调节因子和治疗靶点（综述）。
Int J Oncol. 2024 Sep;65(3). doi: 10.3892/ijo.2024.5673. Epub 2024 Jul 26.
本文引用的文献
1
Enzyme-Linked Immunosorbent Spot Assay for the Detection of Wilms' Tumor 1-Specific T Cells Induced by Dendritic Cell Vaccination.用于检测树突状细胞疫苗诱导的肾母细胞瘤1特异性T细胞的酶联免疫斑点测定法。
Biomedicines. 2015 Dec 4;3(4):304-315. doi: 10.3390/biomedicines3040304.
2
Dendritic cell-based immunotherapy.基于树突状细胞的免疫疗法。
Cell Res. 2017 Jan;27(1):74-95. doi: 10.1038/cr.2016.157. Epub 2016 Dec 27.
3
Clinical relevance of colorectal cancer molecular subtypes.结直肠癌分子亚型的临床相关性。
Crit Rev Oncol Hematol. 2017 Jan;109:9-19. doi: 10.1016/j.critrevonc.2016.11.007. Epub 2016 Nov 23.
4
Phase II randomised trial of autologous tumour lysate dendritic cell plus best supportive care compared with best supportive care in pre-treated advanced colorectal cancer patients.自体肿瘤裂解物树突状细胞联合最佳支持治疗与最佳支持治疗在经治晚期结直肠癌患者中的II期随机试验。
Eur J Cancer. 2016 Sep;64:167-74. doi: 10.1016/j.ejca.2016.06.008. Epub 2016 Jul 16.
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Oncolytic herpes simplex virus kills stem-like tumor-initiating colon cancer cells.溶瘤单纯疱疹病毒能杀死具有干细胞特性的肿瘤起始结肠癌细胞。
Mol Ther Oncolytics. 2016 Jun 15;3:16013. doi: 10.1038/mto.2016.13. eCollection 2016.
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Dendritic Cell Vaccines.树突状细胞疫苗
Methods Mol Biol. 2016;1403:763-77. doi: 10.1007/978-1-4939-3387-7_44.
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Trial Watch-Oncolytic viruses and cancer therapy.试验观察——溶瘤病毒与癌症治疗
Oncoimmunology. 2015 Dec 8;5(2):e1117740. doi: 10.1080/2162402X.2015.1117740. eCollection 2016 Feb.
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A phase I study of indoximod in patients with advanced malignancies.吲哚莫德用于晚期恶性肿瘤患者的I期研究。
Oncotarget. 2016 Apr 19;7(16):22928-38. doi: 10.18632/oncotarget.8216.
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Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial.阿特珠单抗对比多西他赛用于治疗既往接受过治疗的非小细胞肺癌患者（POPLAR）：一项多中心、开放标签、2 期随机对照临床试验。
Lancet. 2016 Apr 30;387(10030):1837-46. doi: 10.1016/S0140-6736(16)00587-0. Epub 2016 Mar 10.
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Global patterns and trends in colorectal cancer incidence and mortality.全球结直肠癌发病率和死亡率的模式和趋势。
Gut. 2017 Apr;66(4):683-691. doi: 10.1136/gutjnl-2015-310912. Epub 2016 Jan 27.
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