Horwitz D A, Linker-Israeli M, Gray J D, Lemoine C
J Rheumatol Suppl. 1987 Jun;14 Suppl 13:49-52.
CD8+ lymphocytes comprise several cell subpopulations that differ phenotypically and functionally. Although the percentage of T cytotoxic/suppressor cells (CD3+ CD8+) is usually increased in patients with active SLE, these lymphocytes are unable to suppress immunoglobulin (Ig) synthesis. However, freshly prepared lymphocytes from patients with SLE contain CD8+ DR+ cells which spontaneously suppress lymphocyte production of mitogen induced interleukin 2 (IL-2). Furthermore, CD8+ Leu 11+ non-T cells which comprise only 5% of total lymphocytes are also potent suppressors of IL-2 production. At the present time it is not known whether CD8+ suppressors of Ig synthesis and CD8+ suppressors of IL-2 production represent different maturation stages of common precursor cells or represent true heterogeneity of CD8+ lymphocytes.
CD8 + 淋巴细胞由几个在表型和功能上不同的细胞亚群组成。虽然在活动性系统性红斑狼疮（SLE）患者中，细胞毒性/抑制性T细胞（CD3 + CD8 +）的百分比通常会增加，但这些淋巴细胞无法抑制免疫球蛋白（Ig）的合成。然而，来自SLE患者的新鲜制备的淋巴细胞含有CD8 + DR + 细胞，它们能自发抑制有丝分裂原诱导的白细胞介素2（IL - 2）的淋巴细胞产生。此外，仅占总淋巴细胞5% 的CD8 + Leu 11 + 非T细胞也是IL - 2产生的有效抑制剂。目前尚不清楚Ig合成的CD8 + 抑制剂和IL - 2产生的CD8 + 抑制剂是代表共同前体细胞的不同成熟阶段，还是代表CD8 + 淋巴细胞的真正异质性。
