Neuss M N, Akwari O E, Stevenson D F, Goodwin B J
J Natl Med Assoc. 1987 Jun;79(6):669-71.
Painful palmar and plantar erythema is an uncommon systemic complication of chemotherapy and has been reported in association with methotrexate, cystosine arabinoside, doxorubicin, and 5-fluorouracil. The authors report a case in which the syndrome was precipitated by hepatic artery infusion of 5-FUdR. The previous recommendation that treatment of patients developing painful palmar-plantar erythema from other drugs may be successfully resumed using intrahepatic arterial infusion of FUdR must be reconsidered in light of the present report.
掌跖部疼痛性红斑是化疗罕见的全身并发症，已有与甲氨蝶呤、阿糖胞苷、多柔比星和5-氟尿嘧啶相关的报道。作者报告了1例因肝动脉输注5-氟脱氧尿苷引发该综合征的病例。鉴于本报告，先前关于因其他药物发生掌跖部疼痛性红斑的患者可通过肝动脉输注氟脱氧尿苷成功恢复治疗的建议必须重新考虑。
