Department of Radiation Oncology, Medical Faculty and University Hospital, Eberhard Karls University Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.
Section for Biomedical Physics, Department of Radiation Oncology, Medical Faculty and University Hospital, Eberhard Karls University Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.
Strahlenther Onkol. 2018 Aug;194(8):719-726. doi: 10.1007/s00066-018-1292-4. Epub 2018 Mar 21.
The purpose of this study was to demonstrate the feasibility of voxel-wise multiparametric characterization of head and neck squamous cell carcinomas (HNSCC) using hybrid multiparametric magnetic resonance imaging and positron emission tomography with [F]-fluorodesoxyglucose (FDG-PET/MRI) in a radiation treatment planning setup.
Ten patients with locally advanced HNSCC were examined with a combined FDG-PET/MRI in an irradiation planning setup. The multiparametric imaging protocol consisted of FDG-PET, T2-weighted transverse short tau inversion recovery sequence (STIR) and diffusion-weighted MRI (DWI). Primary tumours were manually segmented and quantitative imaging parameters were extracted. PET standardized uptake values (SUV) and DWI apparent diffusion coefficients (ADC) were correlated on a voxel-wise level.
Images acquired in this specialised radiotherapy planning setup achieved good diagnostic quality. Median tumour volume was 4.9 [1.1-42.1] ml. Mean PET SUV and ADC of the primary tumours were 5 ± 2.5 and 1.2 ± 0.3 10 mm/s, respectively. In voxel-wise correlation between ADC values and corresponding FDG SUV of the tumours, a significant negative correlation was observed (r = -0.31 ± 0.27, p < 0.05).
Multiparametric voxel-wise characterization of HNSCC is feasible using combined PET/MRI in a radiation planning setup. This technique may provide novel insights into tumour biology with regard to radiation therapy in the future.
本研究旨在展示使用[F]-氟脱氧葡萄糖（FDG-PET/MRI）混合多参数磁共振成像和正电子发射断层扫描（PET/MRI）在放射治疗计划设置中对头颈部鳞状细胞癌（HNSCC）进行体素多参数特征描述的可行性。
10 例局部晚期 HNSCC 患者在放射治疗计划设置中接受了 FDG-PET/MRI 联合检查。多参数成像方案包括 FDG-PET、T2 加权横向短tau反转恢复序列（STIR）和弥散加权 MRI（DWI）。手动分割原发肿瘤并提取定量成像参数。在体素水平上对 PET 标准化摄取值（SUV）和 DWI 表观扩散系数（ADC）进行相关性分析。
该专门的放射治疗计划设置中获得的图像达到了良好的诊断质量。肿瘤中位数体积为 4.9[1.1-42.1]ml。原发肿瘤的平均 PET SUV 和 ADC 分别为 5±2.5 和 1.2±0.310mm/s。在肿瘤 ADC 值与相应 FDG SUV 的体素水平相关性分析中，观察到显著的负相关（r=-0.31±0.27，p<0.05）。
在放射治疗计划设置中，使用 FDG-PET/MRI 联合进行 HNSCC 的多参数体素特征描述是可行的。该技术可能为未来放射治疗中的肿瘤生物学提供新的见解。
