Schapiro M B, Creasey H, Schwartz M, Haxby J V, White B, Moore A, Rapoport S I
Neurology. 1987 Aug;37(8):1424-7. doi: 10.1212/wnl.37.8.1424.
Quantitative CT demonstrated that healthy adults with Down's syndrome (DS) have smaller brains and smaller intracranial volumes than controls. Normalized volumes of CSF, ventricles, and brain parenchyma did not differ in patients and controls. Both DS subjects and controls showed similar significant age-related increments in volumes of CSF and ventricles. Of seven older DS subjects, one was demented, whereas the group as a whole showed reductions in cognitive test scores as compared with younger DS subjects. The results demonstrate cognitive decline in older DS subjects, but no brain atrophy other than that expected with aging.
定量CT显示，患有唐氏综合征（DS）的健康成年人与对照组相比，脑容量和颅内体积更小。患者和对照组的脑脊液、脑室和脑实质的标准化体积没有差异。DS受试者和对照组在脑脊液和脑室体积方面均显示出与年龄相关的显著增加。在7名老年DS受试者中，1名患有痴呆症，而与年轻DS受试者相比，该组整体认知测试得分有所下降。结果表明老年DS受试者存在认知衰退，但除了与衰老相关的脑萎缩外，没有其他脑萎缩。
