School of Chemistry, University of Hyderabad, Gachibowli, Hyderabad - 500 046, India.
Org Biomol Chem. 2018 May 23;16(20):3732-3740. doi: 10.1039/C8OB00263K.
The first total synthesis of a structurally diverse mixed ligand siderophore, gobichelin B produced by Streptomyces sp. NRRL F-4415, is reported. The systematic assembly of the building blocks to synthesize Gob-B 1st half and Gob-B 2nd half and subsequent coupling of these two fragments followed by global deprotection using Pearlman's catalyst led to the isolation of gobichelin B in excellent yield and purity.
报道了结构多样的混合配体铁载体 Gobichelin B 的首次全合成，该化合物由链霉菌 NRRL F-4415 产生。通过系统组装构建块来合成 Gob-B 前半部分和 Gob-B 后半部分，然后使用 Pearlman 催化剂对这两个片段进行偶联，最后进行全局脱保护，得到了 Gobichelin B，产率和纯度都很高。
