联合检测血清 APE1-Abs 和 CEACAM-1 在结直肠癌诊断中的临床价值。

Clinical value of combined detection of serum APE1-Aabs and CEACAM-1 in the diagnosis of colorectal cancer.

机构信息

Jiaxing First Hospital, Jiaxing, Zhejiang Province, China.

出版信息

Eur Rev Med Pharmacol Sci. 2018 Mar;22(5):1286-1289. doi: 10.26355/eurrev_201803_14469.

DOI:10.26355/eurrev_201803_14469

PMID:29565485

Abstract

OBJECTIVE

To analyze the clinical value of combined detection of serum APE1-Aabs and CEACAM-1 in pathological diagnosis of colorectal cancer.

PATIENTS AND METHODS

From December 2014 to July 2016, 60 patients with colorectal cancer and 50 healthy subjects were enrolled in this study. The levels of APE1-AAbs, CEACAM-1 and CEA in the serum were measured, and the clinical value of each index in the diagnosis of colorectal cancer was analyzed.

RESULTS

The level of serum APE1-AAbs in colorectal cancer group was significantly higher than that in healthy control group (p < 0.05). The levels of serum CEACAM-1 and CEA in colorectal cancer patients were significantly higher than those in healthy control group (p < 0.05). The sensitivity and accuracy of APE1-AAbs and CEACAM-1 in the diagnosis of colorectal cancer were significantly higher than separate detection of APE1-AAbs, CEACAM-1 or CEA.

CONCLUSIONS

Combined detection of serum APE1-AAbs and CEACAM-1 has the advantages of high sensitivity and good accuracy in the diagnosis of colorectal cancer, and it is worthy to be popularized in clinical practice.

摘要

目的

分析血清 APE1-Abs 和 CEACAM-1 联合检测在结直肠癌病理诊断中的临床价值。

患者与方法

选取 2014 年 12 月至 2016 年 7 月间我院收治的 60 例结直肠癌患者和 50 例健康体检者作为研究对象，检测血清中 APE1-AAbs、CEACAM-1 和 CEA 的水平，分析各指标在结直肠癌诊断中的临床价值。

结果

结直肠癌组患者血清 APE1-AAbs 水平明显高于健康对照组（p＜0.05），结直肠癌患者血清 CEACAM-1 和 CEA 水平明显高于健康对照组（p＜0.05），APE1-AAbs 和 CEACAM-1 联合检测诊断结直肠癌的灵敏度和准确率明显高于单独检测 APE1-AAbs、CEACAM-1 或 CEA。