Imoh Lucius Chidiebere, Selowo Temitope Toluse, Olaniru Olumide Bamidele, Abene Esala Ezekiel, Gimba Zumnan Mark, Davwar Pantong Mark, Shehu Nathan Yakubu, Onubi Jeremiah, Isichei Christian Ogoegbulam
Department of Chemical Pathology and Metabolic Medicine, Jos University Teaching Hospital, Plateau State, Nigeria.
Department of Medicine, Jos University Teaching Hospital, Plateau State, Nigeria.
Niger Med J. 2024 Sep 26;65(4):490-502. doi: 10.60787/nmj-v65i3-478. eCollection 2024 Jul-Aug.
Obesity is linked to non-communicable conditions. We looked at obesity using four definable criteria and their relationship to biochemical and inflammatory indicators of cardiovascular diseases (CVDs) in people living with HIV (PLHIV).
This cross-sectional study involved 140 randomly selected HIV-infected patients attending HIV clinics at the Jos University Teaching Hospital and Faith Alive Foundation in Jos, Nigeria. Anthropometric measurements such as height, weight, waist circumference, and hip circumference were taken to identify those with obesity. Fasting plasma glucose, lipid profile, High-sensitivity CRP (hsCRP), and HIV-related markers were evaluated.
The mean (SD) age of the participants was 42.5 (8.8) years, and the majority (71.4%) were females. The prevalence of Obesity based on Body-Mass-Index (BMI), International Diabetes Federation (IDF), Adult Treatment Panel (ATP), and Waist-Hip-Ratio (WHR) criteria were 18.6%, 50.7% 34.3%, and 45.7% respectively. Obesity concordance among the criteria for obesity was highest between IDF and ATP (Kappa= 0.673, p<0.001); and least between BMI vs WHR (Kappa= 0.124, p<0.073). Only 9.3% had obesity by all 4 criteria. BMI was independently associated with hypertension but not glycaemic status nor dyslipidaemia while Obesity by WHR was significantly associated with hypertension and dyslipidaemia, after adjusting for age and sex. There was no significant association between Obesity by all the criteria and HIV-related parameters such as duration of HIV infection, Antiretroviral (ARV) use, and CD4 counts (p>0.05).
Our study urges a unified assessment of obesity and a more prominent use of parameters of central obesity, for assessing cardiovascular risk in PLHIV.
肥胖与非传染性疾病相关。我们使用四种可定义的标准来研究肥胖及其与尼日利亚乔斯市乔斯大学教学医院和信仰生活基金会艾滋病诊所中艾滋病毒感染者（PLHIV）心血管疾病（CVD）的生化和炎症指标之间的关系。
这项横断面研究涉及140名随机选择的在尼日利亚乔斯市乔斯大学教学医院和信仰生活基金会艾滋病诊所就诊的艾滋病毒感染患者。通过测量身高、体重、腰围和臀围等人体测量指标来确定肥胖者。评估空腹血糖、血脂谱、高敏C反应蛋白（hsCRP）和艾滋病毒相关标志物。
参与者的平均（标准差）年龄为42.5（8.8）岁，大多数（71.4%）为女性。基于体重指数（BMI）、国际糖尿病联盟（IDF）、成人治疗小组（ATP）和腰臀比（WHR）标准的肥胖患病率分别为18.6%、50.7%、34.3%和45.7%。肥胖标准之间的肥胖一致性在IDF和ATP之间最高（Kappa = 0.673，p<0.001）；在BMI与WHR之间最低（Kappa = 0.124，p<0.073）。所有4项标准均判定为肥胖的仅占9.3%。调整年龄和性别后，BMI与高血压独立相关，但与血糖状态和血脂异常无关，而WHR判定的肥胖与高血压和血脂异常显著相关。所有标准判定的肥胖与艾滋病毒相关参数如艾滋病毒感染持续时间、抗逆转录病毒（ARV）使用情况和CD4细胞计数之间无显著关联（p>0.05）。
我们的研究敦促对肥胖进行统一评估，并更突出地使用中心性肥胖参数来评估PLHIV的心血管风险。
