采用 MP2RAGE 对灰质、白质和 CSF 进行分割，同时抑制脑脊液和白质信号。
Segmentation of gray matter, white matter, and CSF with fluid and white matter suppression using MP2RAGE.
机构信息
Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China.
Vascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle, Washington, USA.
出版信息
J Magn Reson Imaging. 2018 Dec;48(6):1540-1550. doi: 10.1002/jmri.26014. Epub 2018 Mar 22.
BACKGROUND
MP2RAGE can generate uniform T -weighted images, which have been used for brain segmentation. However, there remain concerns about carrying out fast brain segmentation.
PURPOSE
To propose an acquisition-based method for fast segmentation of gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) of healthy human brains with fluid and white matter suppression (FLAWS) using MP2RAGE.
STUDY TYPE
Prospective.
SUBJECTS
12 volunteers (23-28 years, seven subjects; 51-62 years, five subjects).
FIELD STRENGTH/SEQUENCES: 3T/3D MPRAGE and FLAWS.
ASSESSMENT
The proposed method was evaluated by calculating tissue volumes and the spatial overlap with the segmentation results from FSL and SPM12. The processing time was recorded.
STATISTICAL TESTS
A paired t-test was used to compare the tissue volumes of the proposed method with those from other segmentation methods RESULTS: For the 12 subjects, the tissue volume difference between the proposed and SPM12 were 3.2 ± 2.8%, 4.2 ± 2.5%, 18.2 ± 13.1% for GM, WM, and CSF, respectively. The relative difference between the proposed and FSL was over 14% for all tissue classes. The spatial overlap between the proposed and other methods were 87-94% for GM and WM and less than 80% for CSF. The GM and WM volumes of the proposed method were not significantly different from those of SPM12 using MPRAGE as the input (P = 0.5540 and P = 0.3115, respectively). The rest of the comparisons all showed significant differences between the proposed and other methods. Statistical analysis of the two subgroups yielded similar results. The mean processing time of one subject was 6.5, 185, and 165 seconds for the proposed method, FSL, and SPM12, respectively.
DATA CONCLUSION
Our method may be accurate for the segmentation of most brain structures using FLAWS. In addition, the proposed method is fast and applicable to the two distinct age ranges.
LEVEL OF EVIDENCE
2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;48:1540-1550.
背景
MP2RAGE 可生成均匀的 T1 加权图像，用于脑分割。然而，对于快速脑分割仍存在一些担忧。
目的
提出一种基于采集的方法，使用 MP2RAGE 对健康人脑的灰质（GM）、白质（WM）和脑脊液（CSF）进行快速分割，同时抑制脑脊液和白质（FLAWS）。
研究类型
前瞻性。
受试者
12 名志愿者（23-28 岁，7 名受试者；51-62 岁，5 名受试者）。
磁场强度/序列：3T/3D MPRAGE 和 FLAWS。
评估
通过计算组织体积和与 FSL 和 SPM12 分割结果的空间重叠来评估所提出的方法。记录处理时间。
统计检验
采用配对 t 检验比较提出的方法与其他分割方法的组织体积差异。
结果
对于 12 名受试者，提出的方法与 SPM12 之间的组织体积差异分别为 GM、WM 和 CSF 为 3.2±2.8%、4.2±2.5%和 18.2±13.1%。与所有组织类别相比，提出的方法与 FSL 的相对差异均超过 14%。提出的方法与其他方法的空间重叠分别为 GM 和 WM 为 87-94%，CSF 为小于 80%。提出的方法的 GM 和 WM 体积与使用 MPRAGE 作为输入的 SPM12 无显著差异（P=0.5540 和 P=0.3115，分别）。其余比较均显示提出的方法与其他方法之间存在显著差异。对两个亚组的统计分析得出了相似的结果。对于每个受试者，提出的方法、FSL 和 SPM12 的平均处理时间分别为 6.5、185 和 165 秒。
数据结论
使用 FLAWS 时，本方法可能对大多数脑结构的分割具有准确性。此外，该方法快速且适用于两个明显不同的年龄范围。
证据水平
2 技术功效：阶段 1 J. Magn. Reson. Imaging 2018;48:1540-1550.
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