新招募的外籍医护人员中水痘带状疱疹病毒和风疹病毒抗体的血清流行率：一项横断面研究。

Seroprevalence of antibodies against varicella zoster virus and rubella virus among newly recruited expatriate healthcare workers: a cross-sectional study.

作者信息

Shady Ibrahim

机构信息

Community Medicine and Public Health Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

出版信息

BMJ Open. 2018 Mar 22;8(3):e019339. doi: 10.1136/bmjopen-2017-019339.

DOI:10.1136/bmjopen-2017-019339

PMID:29567844

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5875672/

Abstract

OBJECTIVES

To assess the state of immunity to varicella zoster virus (VZV) and rubella virus (RV) among newly recruited healthcare workers (HCWs) in Kuwait before they begin work, and to determine whether there are differences in the prevalence of seronegativity according to nationality, gender, age group and occupation group.

SETTING

This cross-sectional study involved analysis of blood samples from workers newly recruited to the Kuwaiti healthcare system.

PARTICIPANTS

All new non- national HCWs recruited during the study period (n=1540).

INTERVENTION

Enzyme-linked immunoassays for VZV-specific and RV-specific IgG were performed.

RESULTS

Among HCWs, 81.9% and 93.5% were immune to VZV and RV, respectively. Male seronegativity was higher than that of females for both viruses. Regarding VZV, the majority of seronegative individuals were Indians (23.5%), followed by Somalis (12.5), Filipinos (6.5) and Egyptians (5.4%); the between-group differences were significant for all groups. The age groups 20-30 and 30-40 years were most likely to be seronegative, with prevalences of 18.2% and 18.9%, respectively. VZV seronegativity was most common among nurses (21.1%) and least common among physicians (9.2%), and the difference was significant. In addition, RV seronegativity was most frequent among Somalis (12.5%) and lowest among Indians (5.3%); other nationalities (Egyptian, Filipino and others) ranged between 9.1% and 9.6%. Seronegative individuals were most frequently in the younger age group (<20 years old) (17.5%), followed by the >40 years old group (10.4%). RV seronegativity was highest among nurses (6.9%) and lowest among physicians (5.2%).

CONCLUSION

The prevalence of seronegativity is highest among Indians for VZV and Somalis for RV, and HCWs aged 20-40 years for VZV and <20 years for RV. For both viruses, the seronegativity rate was highest for male HCWs, and for nurses compared with other HCWs, with physicians having the lowest prevalence of both viruses.

摘要

目的

评估科威特新招募的医护人员在开始工作前对水痘带状疱疹病毒（VZV）和风疹病毒（RV）的免疫状态，并确定血清阴性率在国籍、性别、年龄组和职业组之间是否存在差异。

背景

这项横断面研究涉及对科威特医疗系统新招募工人的血液样本进行分析。

参与者

研究期间招募的所有新的非本国医护人员（n = 1540）。

干预措施

进行VZV特异性和RV特异性IgG的酶联免疫测定。

结果

在医护人员中，分别有81.9%和93.5%的人对VZV和RV免疫。两种病毒的男性血清阴性率均高于女性。关于VZV，大多数血清阴性个体是印度人（23.5%），其次是索马里人（12.5%）、菲律宾人（6.5%）和埃及人（5.4%）；所有组之间的组间差异均具有统计学意义。20 - 30岁和30 - 40岁年龄组最有可能血清阴性，患病率分别为18.2%和18.9%。VZV血清阴性在护士中最常见（21.1%），在医生中最不常见（9.2%），差异具有统计学意义。此外，RV血清阴性在索马里人中最常见（12.5%），在印度人中最低（5.3%）；其他国籍（埃及人、菲律宾人和其他人）在9.1%至9.6%之间。血清阴性个体最常出现在较年轻年龄组（<20岁）（17.5%），其次是>40岁组（10.4%）。RV血清阴性在护士中最高（6.9%），在医生中最低（5.2%）。