伊朗德黑兰一所大学医院医护人员的水痘带状疱疹抗体。

Varicella Zoster antibodies among health care workers in a university hospital, Teheran, Iran.

机构信息

Infectious Disease Department, Iran University of Medical Sciences, Teheran, Iran.

出版信息

Int J Occup Med Environ Health. 2010;23(1):27-32. doi: 10.2478/v10001-010-0011-x.

DOI:10.2478/v10001-010-0011-x

PMID:20442060

Abstract

OBJECTIVES

This study was designed to evaluate the immune status of health care workers against varicella zoster in a university hospital in Teheran, Iran, and to compare the history of chickenpox infection with the presence of varicella antibodies in this population.

METHODS

Serologic testing for varicella was performed for 405 health care workers with different job categories and at different age. The enzyme immunoassay was used for determining IgG antibodies against varicella zoster virus.

RESULTS

A total of 405 health care workers, aged 19-50 years (median: 29 years), were examined. Of these, 289 (71.4%) were found to be seropositive. No statistically significant differences were observed between gender, age, or occupation, and seropositivity (p = 0.09, 0.75, 0.54. respectively). Statistical analysis revealed that the correlation between chickenpox history and seropositivity showed a 62.3% sensitivity, 72.4% specificity, 84.9% positive predictive value, and 43.5% negative predictive value.

CONCLUSIONS

Serologic screening of health care workers is essential to determine their immunity to varicella, regardless of the age, occupation and history of infection. This population is recommended to be considered a target group for future immunization programs in Iran.

摘要

目的

本研究旨在评估伊朗德黑兰一所大学医院医护人员的水痘带状疱疹免疫状态，并比较该人群中水痘感染史与水痘抗体存在情况。

方法

对 405 名不同职业和不同年龄的医护人员进行血清学检测，以确定针对水痘带状疱疹病毒的 IgG 抗体。

结果

共检查了 405 名年龄在 19-50 岁（中位数：29 岁）的医护人员。其中，289 名（71.4%）呈血清阳性。性别、年龄或职业与血清阳性率之间无统计学差异（p=0.09、0.75、0.54，分别）。统计分析显示，水痘病史与血清阳性率之间的相关性具有 62.3%的敏感性、72.4%的特异性、84.9%的阳性预测值和 43.5%的阴性预测值。