Gangadhar Prithal, Pai Muktha R, Sandhya I
Department of Pathology, A. J. Institute of Medical Sciences and Research Centre, Mangalore, Karnataka, India.
Indian J Pathol Microbiol. 2018 Jan-Mar;61(1):127-130. doi: 10.4103/IJPM.IJPM_745_16.
Female urethral carcinoma is extremely rare and accounts for 0.02% of all women's cancers and <1% of cancers in the female genitourinary tract. Adenocarcinoma accounts for only 10% of urethral carcinomas in females. Due to their location, presentation is usually late and tumors are often missed on physical examination. As in this case, nonspecific symptoms in the early stages may delay the diagnosis in most patients. Herein, we present an extremely rare case of the columnar type of primary female urethral adenocarcinoma exhibiting colonic adenocarcinoma features which to the authors' best knowledge has not been reported to date. The present study emphasizes the importance of a careful clinical examination and also highlights the role of imaging studies, and biopsy in making an accurate preoperative diagnosis of this rare disease. The disease may have devastating sequelae due to local and metastatic involvement if not recognized and treated earlier.
女性尿道癌极为罕见，占所有女性癌症的0.02%，占女性泌尿生殖道癌症的不到1%。腺癌仅占女性尿道癌的10%。由于其位置特殊，通常就诊时已属晚期，体格检查时肿瘤常易被漏诊。就像本病例一样，大多数患者早期的非特异性症状可能会延误诊断。在此，我们报告一例极为罕见的柱状型原发性女性尿道腺癌病例，其具有结肠腺癌特征，据作者所知，迄今为止尚未见相关报道。本研究强调了仔细临床检查的重要性，同时也突出了影像学检查和活检在准确术前诊断这种罕见疾病中的作用。如果不及早识别和治疗，该疾病可能因局部和转移累及而产生严重后果。
