Department of Oral and Maxillofacial Surgery, Shanghai Stomatological Hospital, Fudan University, Shanghai, 200001, China.
Oral Biomedical Engineering Laboratory, Shanghai Stomatological Hospital, Fudan University, Shanghai, 200001, China.
Sci Rep. 2018 Mar 22;8(1):5024. doi: 10.1038/s41598-018-23145-4.
Due to the substantial limitation of study population, Spindle cell sarcoma (SCS) was unexplored comprehensively. In this study, we investigated the clinical characteristics and disease specific prognostic factors of SCS. 3299 SCS cases were identified and extracted from Surveillance, Epidemiology, and End Results (SEER) database (1973-2017). White people account for 79.1% with median age of 57 years without predominance in any gender. Significant disease specific survival (DSS) and overall survival (OS) were found differentiated in age, T stage, N stage, M stage, AJCC stage, SEER historic stage, tumor locations, surgery, and pathologic grade. In the multivariate Cox analysis, the age >64 years (for DSS, P < 0.001 and for OS, P < 0.001; Reference age ≤64 years), AJCC stage III (for DSS, P = 0.006 and for OS, P = 0.04; Reference: AJCC stage I), and non-surgical treatment (for DSS, P < 0.001 and for OS, P < 0.001; Reference: surgery) were independently associated with worse DSS and OS. In brief, our study demonstrated that SCS mostly found in white people at fifth to seventh decades of life without gender predilection. The patient's age, AJCC stage, tumor location and surgery were independent prognostic indicators for both DSS and OS of SCS.
由于研究人群的大量限制，梭形细胞肉瘤（SCS）尚未得到全面研究。在这项研究中，我们调查了 SCS 的临床特征和疾病特异性预后因素。从监测、流行病学和最终结果（SEER）数据库（1973-2017 年）中确定并提取了 3299 例 SCS 病例。白人占 79.1%，中位年龄为 57 岁，男女比例无明显差异。在年龄、T 分期、N 分期、M 分期、AJCC 分期、SEER 历史分期、肿瘤部位、手术和病理分级方面，发现了显著的疾病特异性生存（DSS）和总体生存（OS）差异。多变量 Cox 分析显示，年龄>64 岁（DSS，P<0.001；OS，P<0.001；参考年龄≤64 岁）、AJCC 分期 III 期（DSS，P=0.006；OS，P=0.04；参考：AJCC 分期 I 期）和非手术治疗（DSS，P<0.001；OS，P<0.001；参考：手术）与较差的 DSS 和 OS 独立相关。总之，我们的研究表明，SCS 主要发生在 50 至 70 岁的白人中，无性别偏好。患者的年龄、AJCC 分期、肿瘤部位和手术是 SCS 的 DSS 和 OS 的独立预后指标。
