Wohlrab Peter, Kraft Felix, Tretter Verena, Ullrich Roman, Markstaller Klaus, Klein Klaus Ulrich
Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
F1000Res. 2018 Mar 5;7. doi: 10.12688/f1000research.11148.1. eCollection 2018.
Acute respiratory distress syndrome (ARDS) is characterized by acute diffuse lung injury, which results in increased pulmonary vascular permeability and loss of aerated lung tissue. This causes bilateral opacity consistent with pulmonary edema, hypoxemia, increased venous admixture, and decreased lung compliance such that patients with ARDS need supportive care in the intensive care unit to maintain oxygenation and prevent adverse outcomes. Recently, advances in understanding the underlying pathophysiology of ARDS led to new approaches in managing these patients. In this review, we want to focus on recent scientific evidence in the field of ARDS research and discuss promising new developments in the treatment of this disease.
急性呼吸窘迫综合征（ARDS）的特征是急性弥漫性肺损伤，这会导致肺血管通透性增加和充气肺组织丧失。这会引起与肺水肿、低氧血症、静脉血掺杂增加和肺顺应性降低相一致的双侧肺实质模糊，使得ARDS患者需要在重症监护病房接受支持治疗以维持氧合并预防不良后果。最近，在理解ARDS潜在病理生理学方面取得的进展带来了管理这些患者的新方法。在本综述中，我们希望聚焦于ARDS研究领域的最新科学证据，并讨论该疾病治疗中前景广阔的新进展。
