Discipline of Biomedical Sciences, Sydney Medical School, The University of Sydney, Cumberland Campus C42, East Street, Lidcombe, NSW 1825, Australia.
Biomed Res Int. 2018 Jan 15;2018:4154185. doi: 10.1155/2018/4154185. eCollection 2018.
Polyphenols have been reported to have wide spectrum of biological activities including major impact on initiation, promotion, and progression of cancer by modulating different signalling pathways. Colorectal cancer is the second most major cause of mortality and morbidity among females and the third among males. The objective of this review is to describe the activity of a variety of polyphenols in colorectal cancer in clinical trials, preclinical studies, and primary research. The molecular mechanisms of major polyphenols related to their beneficial effects on colorectal cancer are also addressed. Synthetic modifications and other future directions towards exploiting of natural polyphenols against colorectal cancer are discussed in the last section.
多酚被报道具有广泛的生物活性，包括通过调节不同的信号通路对癌症的启动、促进和进展产生重大影响。结直肠癌是女性死亡率和发病率的第二大主要原因，也是男性的第三大主要原因。本综述的目的是描述各种多酚在临床试验、临床前研究和基础研究中对结直肠癌的活性。还讨论了与多酚对结直肠癌的有益作用相关的主要多酚的分子机制。最后一节讨论了针对结直肠癌开发天然多酚的合成修饰和其他未来方向。
