College of Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, China.
Anorectal Department, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun 130021, China.
Molecules. 2022 Dec 12;27(24):8810. doi: 10.3390/molecules27248810.
Colorectal cancer (CRC) is a prevalent and serious gastrointestinal malignancy with high mortality and morbidity. Chemoprevention refers to a newly emerged strategy that uses drugs with chemopreventive properties to promote antioxidation, regulate cancer cell cycle, suppress proliferation, and induce cellular apoptosis, so as to improve cancer treatment outcomes. Natural polyphenols are currently recognized as a class of chemopreventive agents that have shown remarkable anticarcinogenic properties. Numerous in vitro and in vivo studies have elucidated the anti-CRC mechanisms of natural polyphenols, such as regulation of various molecular and signaling pathways. Natural polyphenols are also reportedly capable of modulating the gut microbiota and cancer stem cells (CSCs) to suppress tumor formation and progression. Combined use of different natural polyphenols is recommended due to their low bioavailability and instability, and combination treatment can exert synergistical effects, reduce side effects, and avoid drug resistance in CRC treatment. In summary, the application of polyphenols in the chemoprevention and treatment of CRC is promising. Further clinical evaluation of their effectiveness is warranted and anticipated.
结直肠癌（CRC）是一种常见且严重的胃肠道恶性肿瘤，具有高死亡率和发病率。化学预防是一种新兴的策略，它使用具有化学预防特性的药物来促进抗氧化、调节癌细胞周期、抑制增殖和诱导细胞凋亡，从而改善癌症治疗效果。天然多酚类化合物目前被认为是一类化学预防剂，具有显著的抗癌特性。大量的体外和体内研究阐明了天然多酚类化合物的抗 CRC 机制，例如调节各种分子和信号通路。据报道，天然多酚类化合物还能够调节肠道微生物群和癌症干细胞（CSCs），抑制肿瘤的形成和发展。由于其生物利用度低和不稳定性，建议联合使用不同的天然多酚类化合物，联合治疗可以发挥协同作用，减少副作用，并避免 CRC 治疗中的耐药性。总之，多酚类化合物在 CRC 的化学预防和治疗中的应用具有广阔的前景。需要进一步评估其有效性并进行临床验证。
