来自漏斗石斛的新二氢菲类化合物。

New dihydrophenanthrenes from Dendrobium infundibulum.

作者信息

Na Ranong Salinee, Likhitwitayawuid Kittisak, Mekboonsonglarp Wanwimon, Sritularak Boonchoo

机构信息

a Faculty of Pharmaceutical Sciences, Department of Pharmacognosy and Pharmaceutical Botany, Chulalongkorn University , Bangkok , Thailand.

b Scientific and Technological Research Equipment Centre Chulalongkorn University , Bangkok , Thailand.

出版信息

Nat Prod Res. 2019 Feb;33(3):420-426. doi: 10.1080/14786419.2018.1455050. Epub 2018 Mar 23.

DOI:10.1080/14786419.2018.1455050

PMID:29569485

Abstract

Two new dihydrophenanthrenes, dendroinfundin A (1) and dendroinfundin B (2) were isolated from the whole plant of Dendrobium infundibulum, together with 7 known compounds (3-9). The structures of the new compounds (1 and 2) were established on the basis of their spectroscopic data. All of the isolates were evaluated for their α-glucosidase and pancreatic lipase inhibitory activities. Batatasin III (5) and dendrosinen B (9) showed strong α-glucosidase inhibitory activity. Dendrosinen B (9) also exhibited appreciable pancreatic lipase inhibitory effect.

摘要

从漏斗石斛全株中分离得到两种新的二氢菲类化合物，漏斗石斛素A（1）和漏斗石斛素B（2），以及7种已知化合物（3 - 9）。根据新化合物（1和2）的光谱数据确定了它们的结构。对所有分离物进行了α - 葡萄糖苷酶和胰脂肪酶抑制活性评估。Batatasin III（5）和石斛碱B（9）表现出较强的α - 葡萄糖苷酶抑制活性。石斛碱B（9）也表现出明显的胰脂肪酶抑制作用。