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一名非血缘供者脐血移植受者发生与播散性结核感染相关的矛盾性免疫重建炎症综合征。

Paradoxical immune reconstitution inflammatory syndrome associated with disseminated tuberculosis infection in an unrelated donor cord blood transplant recipient.

作者信息

Lee Yeon Joo, Bacchus Melissa, Schmidt Elizabeth, Chawla Mohit, Barker Juliet N, Papanicolaou Genovefa A

机构信息

Department of Medicine, Infectious Diseases Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Weill Cornell Medical College, New York, NY, USA.

出版信息

Transpl Infect Dis. 2018 Jun;20(3):e12889. doi: 10.1111/tid.12889. Epub 2018 Apr 3.

DOI:10.1111/tid.12889
PMID:29569815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6755669/
Abstract

Tuberculosis (TB) is an infrequent infection after hematopoietic cell transplant (HCT), with associated mortality up to 30%. The utility of universal screening for latent TB in HCT candidates is controversial due to the lack of sensitive screening tests. We describe a case of disseminated TB infection complicated by immune reconstitution inflammatory syndrome in an adult double unit umbilical cord blood transplant recipient who originated from the United Arab Emirates.

摘要

结核病（TB）是造血细胞移植（HCT）后较少见的感染，相关死亡率高达30%。由于缺乏敏感的筛查试验，对HCT候选者进行潜伏性结核普遍筛查的效用存在争议。我们描述了一例来自阿拉伯联合酋长国的成年双单位脐带血移植受者发生播散性结核感染并并发免疫重建炎症综合征的病例。

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Paradoxical immune reconstitution inflammatory syndrome associated with disseminated tuberculosis infection in an unrelated donor cord blood transplant recipient.一名非血缘供者脐血移植受者发生与播散性结核感染相关的矛盾性免疫重建炎症综合征。
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本文引用的文献

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Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children.美国胸科学会/传染病学会/疾病控制与预防中心临床实践指南：成人和儿童结核病诊断。
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Clin Infect Dis. 2011 Jul 15;53(2):168-76. doi: 10.1093/cid/cir276.
7
Immune reconstitution after allogeneic transplantation and expanding options for immunomodulation: an update.异基因移植后的免疫重建和免疫调节选择的扩展：最新进展。
Blood. 2010 May 13;115(19):3861-8. doi: 10.1182/blood-2009-12-234096. Epub 2010 Mar 9.
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Performance of the tuberculin skin test and interferon-gamma release assay for detection of tuberculosis infection in immunocompromised patients in a BCG-vaccinated population.在卡介苗接种人群中，免疫功能低下患者的结核菌素皮肤试验和干扰素-γ释放试验在检测结核感染方面的表现。
BMC Infect Dis. 2009 Dec 15;9:207. doi: 10.1186/1471-2334-9-207.
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Biol Blood Marrow Transplant. 2009 Oct;15(10):1143-238. doi: 10.1016/j.bbmt.2009.06.019.
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