Mallinckrodt Institute of Radiology, School of Medicine, Washington University, St. Louis, MO, USA.
Department of Neurology, School of Medicine, Washington University, St. Louis, MO, USA.
J Cereb Blood Flow Metab. 2019 Oct;39(10):2096-2102. doi: 10.1177/0271678X18767005. Epub 2018 Mar 23.
Glucose and oxygen metabolism are tightly coupled in the human brain, with the preponderance of the brain's glucose supply used to generate ATP via oxidative phosphorylation. A fraction of glucose is consumed outside of oxidative phosphorylation despite the presence of sufficient oxygen to do so. We refer to this process as aerobic glycolysis. A recent positron emission tomography study reported that aerobic glycolysis is uniform within gray matter. Here, we analyze the same data and demonstrate robust regional differences in aerobic glycolysis within gray matter, a finding consistent with previously published data.
葡萄糖和氧气代谢在人类大脑中紧密耦合，大脑葡萄糖供应的大部分用于通过氧化磷酸化产生 ATP。尽管存在足够的氧气，但仍有一部分葡萄糖在氧化磷酸化之外被消耗。我们将这个过程称为有氧糖酵解。最近的一项正电子发射断层扫描研究报告称，有氧糖酵解在灰质内是均匀的。在这里，我们分析了相同的数据，并证明了灰质内有氧糖酵解存在显著的区域差异，这一发现与先前发表的数据一致。
