米卡芬净治疗儿童侵袭性念珠菌病的突破性进展。
Breakthrough Candidemia In Children On Micafungin.
机构信息
From the Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan.
Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee.
出版信息
Pediatr Infect Dis J. 2018 Dec;37(12):1258-1260. doi: 10.1097/INF.0000000000002020.
We identified 8 pediatric patients on micafungin (MCFG; ≥3 doses) at our institution who had breakthrough candidemia (BC). The causative strains of the BC were Candida parapsilosis in 7 patients. The minimum inhibitory concentration of MCFG was ≤1 µg/mL (susceptible) in all 8 isolates. Immunocompromised patients may develop BC caused by MCFG-susceptible strains.
我们在本机构发现了 8 例接受米卡芬净（MCFG；≥3 剂）治疗的儿科患者出现突破性念珠菌血症（BC）。7 例患者的 BC 致病菌株为近平滑念珠菌。所有 8 株分离株的 MCFG 最低抑菌浓度均≤1µg/mL（敏感）。免疫功能低下的患者可能会出现由 MCFG 敏感株引起的 BC。
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