From the Department of Epidemiology, School of Public Health, Fudan University.
Key Laboratory of Public Health Safety, Ministry of Education.
Pediatr Infect Dis J. 2018 Dec;37(12):1242-1247. doi: 10.1097/INF.0000000000002016.
Data on hospitalization burden of community-acquired pneumonia (CAP) in children are very limited in China. This study aimed to estimate the hospitalization rate (HR) and population-based incidence of hospitalization of CAP for children <15 years of age in Suzhou, China.
This was a retrospective study of children hospitalized in Soochow University Affiliated Children's Hospital from January 2010 to December 2014. Children who were residents of downtown Suzhou, 29 days to <15 years of age, with discharge diagnosis codes (International Classification of Diseases, 10th revision) including J09-J18 and J20-J22 were included. All-cause clinical community-acquired pneumonia (CCAP) and radiographically confirmed pneumonia (RCAP) were identified based on individual medical chart review. The HR and population-based cumulative incidence of hospitalization (HI) were calculated.
Among 184,734 children <15 years of age admitted to Soochow University Affiliated Children's Hospital during the study period, 31,302 children were identified as having CCAP and 24,218 (77.4%) children confirmed as having RCAP. CCAP hospitalization occurred year round and peaked during winter and early spring. The overall HRs for CCAP and RCAP were 189.0 [95% confidence interval (CI): 187.1-190.9] and 146.2 (95% CI: 144-148) per 1000 hospitalizations, respectively, and the HIs per 100,000 children annually were CCAP, 3235.8 (95% CI: 3207.3-3264.2) and RCAP, 2503.5 (95% CI: 2478.3-2528.6). For children <5 years of age, the HR for CCAP was 248.4 (95% CI: 245.9-250.9) and RCAP was 194.0 (95% CI: 191.4-196.3) per 1000 hospitalizations; the HI for CCAP was 6956.2 (95% CI: 6892.8-7019.6) and 5431.9 (95% CI: 5375.4-5488.4) per 100,000 children for RCAP. The highest HR and HI were observed in children 29 days to <6 months of age: HR for CCAP was 407.4 (95% CI: 400.9-413.9) per 1000 hospitalizations and HI for CCAP was 11,203.7 (95% CI: 11,026.8-11,380.6) per 100,000 children annually.
There is a considerable burden of CAP among children <15 years of age in Suzhou, particularly among children 29 days to <6 months of age and during winter and early spring. These data provide valuable information to monitor CAP trends over time in children of Suzhou, China.
中国有关社区获得性肺炎（CAP）住院负担的数据非常有限。本研究旨在评估中国苏州<15 岁儿童的 CAP 住院率（HR）和基于人群的住院发病率。
这是一项对 2010 年 1 月至 2014 年 12 月苏州大学附属儿童医院住院的儿童进行的回顾性研究。研究对象为苏州市区居民，年龄 29 天至<15 岁，出院诊断编码（国际疾病分类，第 10 版）包括 J09-J18 和 J20-J22。根据个体病历审查，确定所有病因临床社区获得性肺炎（CCAP）和放射学确诊肺炎（RCAP）。计算了 HR 和基于人群的累积住院发病率（HI）。
在研究期间，苏州大学附属儿童医院收治的<15 岁儿童中，有 184734 例被诊断为 CCAP，其中 31302 例为 CCAP，24218 例（77.4%）为 RCAP。CCAP 住院发生在全年，冬季和早春达到高峰。CCAP 和 RCAP 的总 HR 分别为 189.0[95%置信区间（CI）：187.1-190.9]和 146.2（95% CI：144-148）/1000 次住院，每年每 10 万儿童的 HI 分别为 CCAP，3235.8（95% CI：3207.3-3264.2）和 RCAP，2503.5（95% CI：2478.3-2528.6）。对于<5 岁的儿童，CCAP 的 HR 为 248.4[95% CI：245.9-250.9]，RCAP 的 HR 为 194.0（95% CI：191.4-196.3）/1000 次住院；CCAP 的 HI 为 6956.2（95% CI：6892.8-7019.6），RCAP 的 HI 为 5431.9（95% CI：5375.4-5488.4）/10 万儿童。29 天至<6 个月的儿童 HR 和 HI 最高：CCAP 的 HR 为 407.4（95% CI：400.9-413.9）/1000 次住院，CCAP 的 HI 为 11203.7（95% CI：11026.8-11380.6）/10 万儿童。
苏州<15 岁儿童 CAP 的负担相当大，特别是 29 天至<6 个月的儿童和冬季及早春。这些数据为监测中国苏州儿童 CAP 的趋势提供了有价值的信息。
