Department of Polymeric Materials and Engineering, School of Materials and Energy, Guangdong University of Technology, Guangzhou, 510006, China.
Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter, Guangzhou, 510006, China.
Macromol Rapid Commun. 2018 May;39(9):e1700871. doi: 10.1002/marc.201700871. Epub 2018 Mar 23.
Enzyme catalysis is a mild, efficient, and selective technique that has many applications in organic synthesis as well as polymer synthesis. Here, a novel enzyme-catalysis-induced reversible addition-fragmentation chain transfer (RAFT)-mediated dispersion polymerization for preparing AB diblock copolymer nano-objects with complex morphologies at room temperature is described. Taking advantage of the room-temperature feature, it is shown that pure, worm-like polymer nano-objects can be readily prepared by just monitoring the viscosity. Moreover, it is demonstrated that inorganic nanoparticles and proteins can be loaded in situ into vesicles by this method. Finally, a novel oxygen-tolerant RAFT-mediated dispersion polymerization initiated by enzyme cascade reaction that can be carried out in open vessels is developed. The enzyme-initiated RAFT dispersion polymerization provides a facile platform for the synthesis of various functional polymer nano-objects under mild conditions.
酶催化是一种温和、高效、选择性的技术，在有机合成以及聚合物合成中有许多应用。在这里，我们描述了一种新颖的酶催化诱导的可逆加成-断裂链转移（RAFT）介导的分散聚合，可在室温下制备具有复杂形貌的 AB 两嵌段共聚物纳米物体。利用室温的特点，我们发现只需监测黏度即可轻松制备出纯的、蠕虫状的聚合物纳米物体。此外，我们还证明了通过这种方法可以将无机纳米粒子和蛋白质原位载入囊泡中。最后，我们开发了一种新型的耐氧 RAFT 介导的酶级联反应引发的可在开放容器中进行的分散聚合。酶引发的 RAFT 分散聚合为在温和条件下合成各种功能聚合物纳米物体提供了一个简便的平台。
