Yonetani Naoto, Kaji Takashi, Hichijo Atsuko, Nakayama Soichiro, Maeda Kazuhisa, Irahara Minoru
Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
General Perinatal Medical Center, Shikoku Medical Center for Children and Adults, Zentsuji, Japan.
J Obstet Gynaecol Res. 2018 Jun;44(6):1042-1048. doi: 10.1111/jog.13620. Epub 2018 Mar 23.
We aimed to evaluate the effect of prolonged hospitalization for threatened preterm labor (TPL) on maternal and fetal vitamin D status.
This was a retrospective cohort study, spanning 4 years, including 18 women with TPL and 36 women with normal pregnancy who received prenatal care for a singleton pregnancy at our center. TPL cases were women who were admitted to our hospital after the second trimester test for at least 28 days, during which time the third trimester test was also performed. Controls were randomly sampled from women matched for age as well as the season during which the third trimester test was performed. Serum 25-hydroxyvitamin D (25(OH)D) concentration in maternal blood was compared between the two groups at second trimester, third trimester and in the umbilical cord blood at delivery.
The mean ± SD of maternal serum 25(OH)D concentration in the TPL group (14.0 ± 3.0 ng/mL) was significantly lower than that in the control group (17.8 ± 5.9 ng/mL) (P < 0.01) in the third trimester, although there was no significant difference in the second trimester (P = 0.30). There was a significant reduction (P < 0.01) in the maternal serum 25(OH)D from the second to third trimester in the TPL group, compared to the control group (P = 0.60). There was no significant difference between the two groups in umbilical cord blood 25(OH)D concentrations at delivery (P = 0.41).
Prolonged hospitalization for TPL reduced the maternal vitamin D status but did not influence the neonatal status at delivery.
我们旨在评估先兆早产（TPL）患者延长住院时间对母婴维生素D水平的影响。
这是一项回顾性队列研究，为期4年，纳入了18例先兆早产患者和36例单胎妊娠且在本中心接受产前检查的正常妊娠女性。先兆早产病例为孕中期检查后至少住院28天的女性，在此期间还进行了孕晚期检查。对照组从年龄匹配且孕晚期检查季节相同的女性中随机抽取。比较两组在孕中期、孕晚期及分娩时脐血中母体血清25-羟维生素D（25(OH)D）浓度。
孕晚期，先兆早产组母体血清25(OH)D浓度的均值±标准差（14.0±3.0 ng/mL）显著低于对照组（17.8±5.9 ng/mL）（P<0.01），而孕中期两组间无显著差异（P = 0.30）。与对照组（P = 0.60）相比，先兆早产组母体血清25(OH)D从孕中期到孕晚期显著降低（P<0.01）。两组分娩时脐血25(OH)D浓度无显著差异（P = 0.41）。
先兆早产患者延长住院时间会降低母体维生素D水平，但不影响分娩时新生儿的维生素D水平。
